The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study.
ageing
disability-free survival
healthspan
late-life depression
psychiatry
Journal
Acta psychiatrica Scandinavica
ISSN: 1600-0447
Titre abrégé: Acta Psychiatr Scand
Pays: United States
ID NLM: 0370364
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
11
10
2022
received:
21
07
2022
accepted:
20
10
2022
pmc-release:
01
01
2024
pubmed:
26
10
2022
medline:
21
12
2022
entrez:
25
10
2022
Statut:
ppublish
Résumé
Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan. This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3-7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability. A total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23-1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03-1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes. LLD may be a common and important risk factor for shortened healthspan.
Sections du résumé
BACKGROUND
Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan.
METHODS
This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3-7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability.
RESULTS
A total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23-1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03-1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes.
CONCLUSIONS
LLD may be a common and important risk factor for shortened healthspan.
Identifiants
pubmed: 36281968
doi: 10.1111/acps.13513
pmc: PMC10026010
mid: NIHMS1878680
doi:
Substances chimiques
Antidepressive Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-104Subventions
Organisme : NIA NIH HHS
ID : U01 AG029824
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG062682
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
Références
Popul Health Manag. 2019 Apr;22(2):127-137
pubmed: 30096023
J Am Geriatr Soc. 2020 Aug;68(8):1834-1841
pubmed: 32402115
Am J Geriatr Psychiatry. 2001 Spring;9(2):113-35
pubmed: 11316616
Contemp Clin Trials. 2005 Apr;26(2):141-54
pubmed: 15837437
PLoS One. 2015 Jun 26;10(6):e0130747
pubmed: 26115099
Sci Rep. 2020 Apr 24;10(1):6955
pubmed: 32332825
Int J Geriatr Psychiatry. 2019 Aug;34(8):1208-1216
pubmed: 30989707
J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):254-260
pubmed: 29415276
Front Pharmacol. 2020 Feb 07;11:34
pubmed: 32116710
Br J Psychiatry. 2019 Aug;215(2):449-455
pubmed: 30968781
JAMA Netw Open. 2019 Jul 3;2(7):e196870
pubmed: 31290992
Health Promot Chronic Dis Prev Can. 2016 Oct;36(10):205-213
pubmed: 27768557
Neurosci Biobehav Rev. 2022 Jan;132:1067-1073
pubmed: 34742925
Lancet. 2018 Nov 10;392(10159):1684-1735
pubmed: 30496102
Br J Psychiatry. 2013 May;202(5):329-35
pubmed: 23637108
Nat Rev Cardiol. 2012 Sep;9(9):526-39
pubmed: 22733213
Neurosci Biobehav Rev. 2019 Dec;107:862-882
pubmed: 31545987
Prev Med. 2016 Oct;91:144-151
pubmed: 27514249
J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):2007-2014
pubmed: 33367621
Int J Epidemiol. 2016 Aug;45(4):1260-1270
pubmed: 27488415
Int J Geriatr Psychiatry. 2008 Jun;23(6):643-9
pubmed: 18044794
Clin Interv Aging. 2015 Dec 15;10:1947-58
pubmed: 26719681
Am J Geriatr Psychiatry. 2015 May;23(5):488-94
pubmed: 25047306
J Clin Psychiatry. 1987 Aug;48(8):314-8
pubmed: 3611032
Am J Prev Med. 1994 Mar-Apr;10(2):77-84
pubmed: 8037935
J Affect Disord. 2021 Sep 1;292:454-463
pubmed: 34144371
N Engl J Med. 2018 Oct 18;379(16):1499-1508
pubmed: 30221596
Gerontologist. 2015 Dec;55(6):901-11
pubmed: 26561272