Maternal stress and mental health before pregnancy and offspring diurnal cortisol in early childhood.
HPA axis
PTSD
depression
preconception
stress
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
01
07
2022
received:
14
02
2022
accepted:
08
07
2022
entrez:
25
10
2022
pubmed:
26
10
2022
medline:
28
10
2022
Statut:
ppublish
Résumé
The current study investigates whether prepregnancy maternal posttraumatic stress disorder (PTSD) symptoms, depressive symptoms, and stress predict children's cortisol diurnal slopes and cortisol awakening responses (CARs) adjusting for relevant variables. Mothers were enrolled after delivering a baby and followed through their subsequent pregnancy with 5 years of longitudinal data on their subsequent child. This prospective design allowed assessment of PTSD symptoms, depressive symptoms, and perceived stress prior to pregnancy. Children provided three saliva samples per day on three consecutive days at two timepoints in early childhood (M age = 3.7 years, SD = 0.38; M age = 5.04 years, SD = 0.43). Mothers' PTSD symptoms prior to pregnancy were significantly associated with flatter child diurnal cortisol slopes at 4 and 5 years, but not with child CAR. Findings at the age of 4 years, but not 5 years, remained statistically significant after adjustment for maternal socioeconomic status, race/ethnicity, child age, and other covariates. In contrast, maternal prepregnancy depressive symptoms and perceived stress did not significantly predict cortisol slopes or CAR. Results suggest that maternal prepregnancy PTSD symptoms may contribute to variation in early childhood physiology. This study extends earlier work demonstrating risk of adverse outcomes among children whose mothers experienced trauma but associations cannot be disentangled from effects of prenatal mental health of mothers on children's early childhood.
Identifiants
pubmed: 36282760
doi: 10.1002/dev.22314
pmc: PMC10111814
mid: NIHMS1883324
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22314Subventions
Organisme : NICHD NIH HHS
ID : U01 HD044207
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD059584
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072021
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD054791
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD044245
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD044253
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD044226
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD044219
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH015750
Pays : United States
Organisme : NINR NIH HHS
ID : U01 NR008929
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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