Aspirin-Exacerbated Respiratory Disease and the Unified Airway: A Contemporary Review.
Aspirin intolerance
Aspirin-exacerbated respiratory disease
Asthma
Biological agents
Chronic rhinosinusitis with nasal polyposis
NSAID intolerance
Samter's Triad
Journal
Otolaryngologic clinics of North America
ISSN: 1557-8259
Titre abrégé: Otolaryngol Clin North Am
Pays: United States
ID NLM: 0144042
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
pubmed:
26
10
2022
medline:
24
11
2022
entrez:
25
10
2022
Statut:
ppublish
Résumé
Aspirin-exacerbated respiratory disease (AERD) is characterized by abnormal arachidonic acid metabolism leading to chronic rhinosinusitis with nasal polyposis (CRSwNP), asthma, and upper and/or lower respiratory symptoms after ingestion of cyclooxygenase-1 inhibiting nonsteroidal antiinflammatory drugs. Diagnosis is clinical and may involve an aspirin challenge. Inflammatory biomarkers may be useful for diagnosis and treatment monitoring. Conventional medical management for asthma and CRSwNP is often inadequate. Endoscopic sinus surgery followed by continued medical management with or without aspirin desensitization frequently improves symptoms and objective disease measures. Biological agents targeting eosinophilic inflammation are promising alternatives to conventional management.
Identifiants
pubmed: 36283868
pii: S0030-6665(22)00130-X
doi: 10.1016/j.otc.2022.09.008
pii:
doi:
Substances chimiques
Aspirin
R16CO5Y76E
Anti-Inflammatory Agents, Non-Steroidal
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-124Informations de copyright
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