Sleep-related breathing disorder in non-infectious pulmonary complications after pediatric allogeneic stem cell transplantation.
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
28
02
2022
accepted:
27
09
2022
revised:
31
08
2022
medline:
3
7
2023
pubmed:
26
10
2022
entrez:
25
10
2022
Statut:
ppublish
Résumé
Chronic lung problems are a rare but serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). We studied clinical phenotypes and polysomnography appearance of breathing abnormality in late onset non-infectious pulmonary complications (NIPS). We reviewed Finnish national reference database between the years 1999 and 2016. We identified 12 children with most severely decreased pulmonary function and performed polysomnography and 24 aged-matched controls out of 325 performed pediatric allogeneic HSCTs. All patients with NIPS had severely decreased pulmonary function already at 6 months post HSCT with median FEV Children going through allogeneic HSCT who develop severe chronic obstructive lung function are more likely to present with sleep-related hypoxia and hypoventilation than children with restrictive lung function. Children with severe obstructive lung function and chronic lung graft-versus-host disease following hematopoietic stem cell transplantation are more likely to present with sleep-related mild hypoxia and hypoventilation than children with restrictive lung disease. To our knowledge there are no reports on sleep-related breathing disorders and ventilatory function measured by polysomnography in children with pulmonary complications after allogeneic HSCT. Polysomnography may add to the differential diagnostics between patients with BOS and other non-infectious pulmonary complications.
Sections du résumé
BACKGROUND
BACKGROUND
Chronic lung problems are a rare but serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). We studied clinical phenotypes and polysomnography appearance of breathing abnormality in late onset non-infectious pulmonary complications (NIPS).
METHODS
METHODS
We reviewed Finnish national reference database between the years 1999 and 2016. We identified 12 children with most severely decreased pulmonary function and performed polysomnography and 24 aged-matched controls out of 325 performed pediatric allogeneic HSCTs.
RESULTS
RESULTS
All patients with NIPS had severely decreased pulmonary function already at 6 months post HSCT with median FEV
CONCLUSIONS
CONCLUSIONS
Children going through allogeneic HSCT who develop severe chronic obstructive lung function are more likely to present with sleep-related hypoxia and hypoventilation than children with restrictive lung function.
IMPACT
CONCLUSIONS
Children with severe obstructive lung function and chronic lung graft-versus-host disease following hematopoietic stem cell transplantation are more likely to present with sleep-related mild hypoxia and hypoventilation than children with restrictive lung disease. To our knowledge there are no reports on sleep-related breathing disorders and ventilatory function measured by polysomnography in children with pulmonary complications after allogeneic HSCT. Polysomnography may add to the differential diagnostics between patients with BOS and other non-infectious pulmonary complications.
Identifiants
pubmed: 36284141
doi: 10.1038/s41390-022-02339-7
pii: 10.1038/s41390-022-02339-7
pmc: PMC10313514
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1983-1989Informations de copyright
© 2022. The Author(s).
Références
Slavin, S. et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 91, 756–763 (1998).
doi: 10.1182/blood.V91.3.756
pubmed: 9446633
Peters, C. et al. Total body irradiation or chemotherapy conditioning in childhood ALL: a multinational, randomized, noninferiority phase III study. J. Clin. Oncol. 39, 295–307 (2021).
Fujii, N. et al. Bronchiolitis obliterans with allogeneic hematopoietic cell transplantation: a 10-year experience of the okayama BMT group. Int J. Hematol. 99, 644–651 (2014).
doi: 10.1007/s12185-014-1556-4
pubmed: 24634108
Thompson, P. A. et al. Screening with spirometry is a useful predictor of later development of noninfectious pulmonary syndromes in patients undergoing allogeneic stem cell transplantation. Biol. Blood Marrow Transplant. 20, 781–786 (2014).
doi: 10.1016/j.bbmt.2014.02.011
pubmed: 24548876
Park, M., Koh, K. N., Kim, B. E., Im, H. J. & Seo, J. J. Clinical features of late onset non-infectious pulmonary complications following pediatric allogeneic hematopoietic stem cell transplantation. Clin. Transplant. 25, 168 (2011).
doi: 10.1111/j.1399-0012.2010.01357.x
Abedin, S. et al. Predictive value of bronchiolitis obliterans syndrome stage 0p in chronic graft-versus-host disease of the lung. Biol. Blood Marrow Transplant. 21, 1127–1131 (2015).
doi: 10.1016/j.bbmt.2015.02.006
pubmed: 25687798
pmcid: 4970454
Ahn, J. H. et al. Prognostic role of FEV1 for survival in bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation. Clin. Transplant. 29, 1133–1139 (2015).
doi: 10.1111/ctr.12638
pubmed: 26383085
Forslöw, U., Mattsson, J., Gustafsson, T. & Remberger, M. Donor lymphocyte infusion may reduce the incidence of bronchiolitis obliterans after allogeneic stem cell transplantation. Biol. Blood Marrow Transplant. 17, 1214–1221 (2011).
doi: 10.1016/j.bbmt.2010.12.701
pubmed: 21193056
Chien, J. W., Duncan, S., Williams, K. M. & Pavletic, S. Z. Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease. Biol. Blood Marrow Transplant. 16, 106 (2010).
doi: 10.1016/j.bbmt.2009.11.002
Hakim, A. Diagnosis and treatment of bronchiolitis obliterans syndrome accessible universally. Bone Marrow Transplant. 54, 383–92 (2019).
doi: 10.1038/s41409-018-0266-6
pubmed: 30038355
Duncan, C. N. Bronchiolitis obliterans following pediatric allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 41, 971–975 (2008).
doi: 10.1038/bmt.2008.19
pubmed: 18297116
Bergeron, A. Late-onset noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation. Clin. Chest Med. 38, 249–262 (2017).
doi: 10.1016/j.ccm.2016.12.013
pubmed: 28477637
Birnkrant, D. J. et al. Diagnosis and management of duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management. Lancet Neurol. 17, 347–361 (2018).
doi: 10.1016/S1474-4422(18)30025-5
pubmed: 29395990
pmcid: 5889091
Mellies, U. Sleep-disordered breathing and respiratory failure in acid maltase deficiency. Neurology 57, 1290–1295 (2001).
doi: 10.1212/WNL.57.7.1290
pubmed: 11591850
Ragette, R., Mellies, U., Schwake, C., Voit, T. & Teschler, H. Patterns and predictors of sleep disordered breathing in primary myopathies. Thorax 57, 724–728 (2002).
doi: 10.1136/thorax.57.8.724
pubmed: 12149535
pmcid: 1746391
Filipovich, A. H. et al. National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and Staging Working Group Report. Biol. Blood Marrow Transplant. 11, 945–956 (2005).
doi: 10.1016/j.bbmt.2005.09.004
pubmed: 16338616
Kaya, Z., Weiner, D. J., Yilmaz, D., Rowan, J. & Goyal, R. K. Lung function, pulmonary complications, and mortality after allogeneic blood and marrow transplantation in children. Biol. Blood Marrow Transplant. 15, 817–826 (2009).
doi: 10.1016/j.bbmt.2009.03.019
pubmed: 19539213
Jagasia, M. H. et al. National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol. Blood Marrow Transplant. 21, 389.e1–401.e1 (2015).
doi: 10.1016/j.bbmt.2014.12.001
Dudek, A. Z., Mahaseth, H., DeFor, T. E. & Weisdorf, D. J. Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. Biol. Blood Marrow Transplant. 9, 657–666 (2003).
doi: 10.1016/S1083-8791(03)00242-8
pubmed: 14569562
Griese, M. Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center. Pediatr. Pulmonol. 30, 393–401 (2000).
doi: 10.1002/1099-0496(200011)30:5<393::AID-PPUL5>3.0.CO;2-W
pubmed: 11064430
Wieringa, J., van Kralingen, K. W., Sont, J. K. & Bresters, D. Pulmonary function impairment in children following hematopoietic stem cell transplantation. Pediatr. Blood Cancer 45, 318–323 (2005).
doi: 10.1002/pbc.20304
pubmed: 15747333
Savani, B. N. et al. Chronic GVHD and pretransplantation abnormalities in pulmonary function are the main determinants predicting worsening pulmonary function in long-term survivors after stem cell transplantation. Biol. Blood Marrow Transplant. 12, 1261–1269 (2006).
doi: 10.1016/j.bbmt.2006.07.016
pubmed: 17162207
pmcid: 1849949
Ueda, K. et al. Outcome and treatment of late-onset noninfectious pulmonary complications after allogeneic haematopoietic SCT. Bone Marrow Transplant. 45, 1719–1727 (2010).
doi: 10.1038/bmt.2010.48
pubmed: 20208571