No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness.
adverse childhood experiences
biological aging
central arterial stiffness
mitochondrial DNA copy number
telomere length
vascular aging
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
pubmed:
27
10
2022
medline:
3
11
2022
entrez:
26
10
2022
Statut:
ppublish
Résumé
Background Adverse childhood experiences (ACEs) have been linked to increased cardiovascular disease (CVD) risk. Previous reports have suggested that accelerated biological aging-indexed by telomere length (TL) and mitochondrial DNA copy number (mtDNAcn)-may contribute to associations between ACEs and cardiovascular health outcomes. Here, we examine the potential mediating effects of TL and mtDNAcn on the association between ACEs and central arterial stiffness-an intermediate cardiovascular health outcome-as a novel pathway linking ACEs to CVD risk among young adults. Methods and Results One hundred and eighty-five (n=102 women; mean age, 22.5±1.5 years) individuals provided information on ACEs. TL (kb per diploid cell) and mtDNAcn (copies per diploid cell) were quantified using quantitative polymerase chain reaction techniques. Central arterial stiffness was measured as carotid-femoral pulse wave velocity (cfPWV; m/s). Multiple linear regression analyses were used to examine the associations between ACEs, TL, mtDNAcn, and cfPWV. ACEs were positively associated with cfPWV (
Identifiants
pubmed: 36285820
doi: 10.1161/JAHA.122.026619
pmc: PMC9673639
doi:
Substances chimiques
DNA, Mitochondrial
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e026619Subventions
Organisme : CIHR
ID : 363774
Pays : Canada
Organisme : CIHR
ID : 399332
Pays : Canada
Organisme : CIHR
ID : RFN 167014
Pays : Canada
Références
Hypertension. 2014 Aug;64(2):210-4
pubmed: 24799614
Front Cell Dev Biol. 2019 Nov 06;7:274
pubmed: 31781563
Hum Genet. 2014 Sep;133(9):1149-59
pubmed: 24902542
Aging Male. 2011 Mar;14(1):27-32
pubmed: 21067315
Hypertension. 2014 Jul;64(1):201-7
pubmed: 24777980
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
Bioessays. 2018 Sep;40(9):e1800077
pubmed: 30067291
Psychol Health. 2016 Dec;31(12):1466-1480
pubmed: 27616348
J Trauma Stress. 2018 Oct;31(5):676-686
pubmed: 30338579
Physiol Rep. 2021 Jun;9(11):e14920
pubmed: 34110720
PLoS One. 2020 Aug 12;15(8):e0237235
pubmed: 32785256
Hypertension. 2001 Feb;37(2 Pt 2):381-5
pubmed: 11230304
Age Ageing. 2021 May 5;50(3):838-846
pubmed: 33001148
Pediatr Res. 2022 Feb;91(3):502-512
pubmed: 33824443
Brain Behav Immun. 2021 Mar;93:254-263
pubmed: 33358983
Mol Psychiatry. 2018 Apr;23(4):858-871
pubmed: 28322278
CMAJ. 2014 Jun 10;186(9):E324-32
pubmed: 24756625
J Am Coll Cardiol. 2020 Mar 3;75(8):919-930
pubmed: 32130928
Biol Lett. 2017 Dec;13(12):
pubmed: 29212750
JAMA. 1999 Nov 3;282(17):1652-8
pubmed: 10553792
Genes (Basel). 2016 Sep 01;7(9):
pubmed: 27598203
J Child Adolesc Trauma. 2020 May 30;13(4):505-514
pubmed: 33269049
Psychol Bull. 2011 Nov;137(6):959-97
pubmed: 21787044
Curr Cardiol Rep. 2015 Oct;17(10):88
pubmed: 26289252
J Gerontol A Biol Sci Med Sci. 2017 Jul 01;72(7):937-944
pubmed: 28329339
Biopreserv Biobank. 2016 Aug;14(4):264-70
pubmed: 27158753
Lancet Public Health. 2019 Oct;4(10):e517-e528
pubmed: 31492648
Br J Psychiatry. 2010 Nov;197(5):378-85
pubmed: 21037215
Nature. 2011 Feb 17;470(7334):359-65
pubmed: 21307849
Mol Reprod Dev. 2000 Sep;57(1):2-3
pubmed: 10954850
Int J Epidemiol. 2013 Feb;42(1):86-96
pubmed: 22434861
Psychosom Med. 2016 Feb-Mar;78(2):171-81
pubmed: 26809108
Child Abuse Negl. 2004 Jul;28(7):729-37
pubmed: 15261468
J Am Coll Cardiol. 2018 Aug 14;72(7):805-813
pubmed: 30092957
Nucleic Acids Res. 2002 May 15;30(10):e47
pubmed: 12000852
Genome Res. 2019 Nov;29(11):1878-1888
pubmed: 31548359
Am J Epidemiol. 2016 Jan 15;183(2):138-46
pubmed: 26702630
Child Abuse Negl. 2016 Jun;56:1-10
pubmed: 27107504
Am J Hum Biol. 2018 Jan;30(1):
pubmed: 28949426
J Am Coll Cardiol. 2007 Jul 3;50(1):1-13
pubmed: 17601538
J Pediatr. 2011 Oct;159(4):584-90
pubmed: 21514597
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
J Hypertens. 2012 Mar;30(3):445-8
pubmed: 22278144
J Psychosom Res. 2015 Apr;78(4):332-9
pubmed: 25736692
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9
pubmed: 9012815
Front Aging Neurosci. 2017 Dec 06;9:397
pubmed: 29270121
Physiol Behav. 2012 Apr 12;106(1):29-39
pubmed: 21888923
Psychosom Med. 2015 Oct;77(8):882-91
pubmed: 26374947
Biol Psychiatry. 2010 Sep 15;68(6):e21-2; author reply e23-4
pubmed: 20678755
N C Med J. 2018 Mar-Apr;79(2):99-103
pubmed: 29563303
Front Biosci (Landmark Ed). 2010 Jan 01;15(1):35-45
pubmed: 20036804
Hypertension. 1989 Nov;14(5):511-7
pubmed: 2807512
J Am Coll Cardiol. 2005 Nov 1;46(9):1753-60
pubmed: 16256881
Transl Psychiatry. 2015 Nov 10;5:e676
pubmed: 26556285
Med Sci Sports Exerc. 2003 Aug;35(8):1381-95
pubmed: 12900694
Front Neurosci. 2019 May 22;13:490
pubmed: 31191214
Psychol Assess. 2014 Sep;26(3):730-40
pubmed: 24819409
J Pers Soc Psychol. 1986 Dec;51(6):1173-82
pubmed: 3806354
Circulation. 2004 Sep 28;110(13):1761-6
pubmed: 15381652
J Clin Endocrinol Metab. 2018 Jan 1;103(1):148-157
pubmed: 29053810
Brain Behav Immun. 2016 May;54:158-169
pubmed: 26853993
Ann Transl Med. 2018 Jun;6(12):256
pubmed: 30069458
Front Immunol. 2017 Sep 04;8:1078
pubmed: 28928745
Genes Dev. 2005 Sep 15;19(18):2100-10
pubmed: 16166375
PLoS One. 2016 Oct 13;11(10):e0163770
pubmed: 27736919
PLoS One. 2019 Apr 26;14(4):e0215085
pubmed: 31026258
JAMA. 2003 Nov 5;290(17):2271-6
pubmed: 14600185
J Am Heart Assoc. 2019 Jun 4;8(11):e012707
pubmed: 31140354
Free Radic Biol Med. 2000 Aug;29(3-4):222-30
pubmed: 11035250
Oncotarget. 2017 Jul 4;8(27):45008-45019
pubmed: 28410238
N Engl J Med. 1998 Jun 4;338(23):1650-6
pubmed: 9614255
Child Abuse Negl. 2001 Feb;25(2):307-12
pubmed: 11330927
Mech Ageing Dev. 2019 Jan;177:37-45
pubmed: 29604323
J Physiol. 2017 Mar 1;595(5):1627-1635
pubmed: 28247509
Int J Endocrinol. 2014;2014:586017
pubmed: 24707289
Heart. 2010 Feb;96(4):298-303
pubmed: 20194205
Hypertension. 2003 Dec;42(6):1206-52
pubmed: 14656957
Biol Proced Online. 2011 Jan 31;13:3
pubmed: 21369534
Psychosom Med. 2011 Jan;73(1):16-22
pubmed: 21148804
PLoS One. 2014 May 09;9(5):e97102
pubmed: 24816913
Hypertension. 2017 Oct;70(4):660-667
pubmed: 28784646
J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27
pubmed: 20338492
Clin Psychol (New York). 2017 Jun;24(2):125-139
pubmed: 28867878
J Psychiatr Res. 2017 Oct;93:64-71
pubmed: 28601667
Biol Psychiatry. 2010 Mar 15;67(6):531-4
pubmed: 19828140
BMC Pediatr. 2013 Dec 17;13:208
pubmed: 24344611
J Pediatr. 2007 Jan;150(1):18-25
pubmed: 17188606
Psychoneuroendocrinology. 2019 Sep;107:261-269
pubmed: 31174164
Int J Environ Res Public Health. 2021 Feb 08;18(4):
pubmed: 33567728
Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H532-H541
pubmed: 34328346
Circulation. 2015 May 12;131(19):1674-81
pubmed: 25858196
Clin Chem Lab Med. 2020 Jan 28;58(2):162-177
pubmed: 31465289
Am Psychol. 2007 May-Jun;62(4):327-8; discussion 330-2
pubmed: 17516786
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):
pubmed: 29335381
Nat Rev Mol Cell Biol. 2012 May 16;13(6):397-404
pubmed: 22588366
Antioxid Redox Signal. 2012 May 15;16(10):1150-80
pubmed: 21967640
Int J Behav Nutr Phys Act. 2011 Oct 21;8:115
pubmed: 22018588
PLoS One. 2018 Nov 7;13(11):e0206003
pubmed: 30403687
Genome. 1989;31(2):553-60
pubmed: 2698831
CMAJ Open. 2021 Mar 2;9(1):E158-E166
pubmed: 33653771
Biol Psychiatry. 2016 Jan 15;79(2):78-86
pubmed: 25749099
Neurosci Biobehav Rev. 2017 Mar;74(Pt B):453-465
pubmed: 27450581
Adv Life Course Res. 2019 Mar;39:34-41
pubmed: 31186623
Curr Opin Cardiol. 2019 May;34(3):270-274
pubmed: 30747731
Hypertension. 2009 Feb;53(2):150-7
pubmed: 19075099
R Soc Open Sci. 2018 Aug 29;5(8):180744
pubmed: 30225068
BMJ Open. 2019 Jul 16;9(7):e030339
pubmed: 31315878
Mol Psychiatry. 2016 May;21(5):642-9
pubmed: 26033244
Dev Psychol. 2015 Nov;51(11):1630-44
pubmed: 26389605
PLoS One. 2017 Jul 13;12(7):e0181036
pubmed: 28704533
Health Psychol Res. 2017 May 16;5(1):6378
pubmed: 28603779
Exp Gerontol. 2015 Jun;66:17-20
pubmed: 25845980
Aging Cell. 2018 Aug;17(4):e12773
pubmed: 29745022
Am J Prev Med. 1998 May;14(4):245-58
pubmed: 9635069
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6335-E6342
pubmed: 27698131
J Am Coll Cardiol. 2019 Nov 19;74(20):2529-2532
pubmed: 31727292
Circulation. 2018 Jan 30;137(5):e15-e28
pubmed: 29254928
Mil Med. 1998 Jan;163(1):20-5
pubmed: 9465567
PLoS One. 2014 Jan 27;9(1):e87348
pubmed: 24475279
Arterioscler Thromb Vasc Biol. 2004 May;24(5):969-74
pubmed: 15001456
Psychol Med. 2015 Oct;45(14):2975-84
pubmed: 26219269
Brain Behav Immun. 2013 Oct;33:65-73
pubmed: 23727245
J Hum Hypertens. 2005 Jul;19(7):507-9
pubmed: 15647777
Heart. 2008 May;94(5):537-9
pubmed: 18411343
Front Biosci (Landmark Ed). 2012 Jan 01;17(5):1715-28
pubmed: 22201831
Eur Heart J. 2006 Nov;27(21):2588-605
pubmed: 17000623
Arch Pediatr Adolesc Med. 2009 Dec;163(12):1135-43
pubmed: 19996051
BMC Res Notes. 2012 Dec 03;5:668
pubmed: 23206278
Vasc Health Risk Manag. 2008;4(3):547-52
pubmed: 18827905
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021
pubmed: 33309175
JAMA Pediatr. 2016 May 1;170(5):466-72
pubmed: 26974359
Mitochondrion. 2013 Sep;13(5):481-92
pubmed: 23085537
Soc Sci Med. 2014 Mar;104:15-22
pubmed: 24581057
Lancet Public Health. 2017 Aug;2(8):e356-e366
pubmed: 29253477
Hypertension. 2018 May;71(5):937-945
pubmed: 29555666