Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer's Disease.
AD
Alzheimer’s disease
SOD2
genetics
oxidative stress
rs4880
variant
Journal
Current issues in molecular biology
ISSN: 1467-3045
Titre abrégé: Curr Issues Mol Biol
Pays: Switzerland
ID NLM: 100931761
Informations de publication
Date de publication:
21 Sep 2022
21 Sep 2022
Historique:
received:
02
08
2022
revised:
16
09
2022
accepted:
16
09
2022
entrez:
26
10
2022
pubmed:
27
10
2022
medline:
27
10
2022
Statut:
epublish
Résumé
A few gene loci that contribute to Alzheimer's Disease (AD) onset have been identified. Few studies have been published about the relationship between SOD2 rs4880 single nucleotide variant and AD, revealing inconsistent results. Therefore, the aim of the current study is to further examine the role of the SOD2 rs4880 in AD. We performed a case-control study with a total of 641 subjects (320 patients with probable AD, and 321 healthy controls). The statistical analysis was performed assuming five genetic models. The threshold for statistical significance was set at 0.05. The results revealed no association between SOD2 rs4880 and AD in any of the assumed genetic models that were examined [log-additive OR = 0.95 (0.76-1.19), over-dominant OR = 1.15 (0.85-1.57), recessive OR = 0.85 (0.59-1.22), dominant OR = 1.03 (0.72-1.47), and co-dominant OR1 = 1.10 (0.75-1.60) and OR2 = 0.90 (0.58-1.40)]. Adjustment for sex and subgroup analyses based on sex did not reveal any statistically significant results either. Based on our findings, SOD2 rs4880 does not appear to play a determining role in the risk of developing AD. Larger studies are warranted to elucidate the connection between rs4880 and AD.
Identifiants
pubmed: 36286017
pii: cimb44100302
doi: 10.3390/cimb44100302
pmc: PMC9600469
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4406-4414Subventions
Organisme : Research Committee of the University of Thessaly, Greece
ID : (code: 5287)
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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