MRI/real-time ultrasound image fusion guided high-intensity focused ultrasound: a prospective comparative and functional analysis of different ablative techniques.
Journal
Minerva urology and nephrology
ISSN: 2724-6442
Titre abrégé: Minerva Urol Nephrol
Pays: Italy
ID NLM: 101777299
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
medline:
3
4
2023
pubmed:
27
10
2022
entrez:
26
10
2022
Statut:
ppublish
Résumé
The aim of this paper was to compare safety and functional outcomes of total, hemi and focal ablation by the latest focal high-intensity focused ultrasound (HIFU) device. This is a prospective study including patients with low to intermediate-risk PCa treated with HIFU by Focal One One hundred patients were enrolled. Median prostate volume and lesion diameter were 46 (IQR 25-75) mL and 10 (IQR 6-13) mm. 15, 50 and 35 patients underwent total, hemi- and focal ablation, respectively. No differences were found between them except for operative time (lower in the focal group, P<0.01). Significant lower incidence of irritative symptoms was identified in the focal group compared to the others (P<0.05 at 1 and 3 months of follow-up). No differences were found among the baseline status and the postoperative assessment in terms of obstructive IPSS items, IIEF-5, QoL, Qmax and PVR (all P value>0.05). Our study suggests that patients' specific HIFU tailoring with the MRI/real-time TRUS Guidance by Focal One
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this paper was to compare safety and functional outcomes of total, hemi and focal ablation by the latest focal high-intensity focused ultrasound (HIFU) device.
METHODS
METHODS
This is a prospective study including patients with low to intermediate-risk PCa treated with HIFU by Focal One
RESULTS
RESULTS
One hundred patients were enrolled. Median prostate volume and lesion diameter were 46 (IQR 25-75) mL and 10 (IQR 6-13) mm. 15, 50 and 35 patients underwent total, hemi- and focal ablation, respectively. No differences were found between them except for operative time (lower in the focal group, P<0.01). Significant lower incidence of irritative symptoms was identified in the focal group compared to the others (P<0.05 at 1 and 3 months of follow-up). No differences were found among the baseline status and the postoperative assessment in terms of obstructive IPSS items, IIEF-5, QoL, Qmax and PVR (all P value>0.05).
CONCLUSIONS
CONCLUSIONS
Our study suggests that patients' specific HIFU tailoring with the MRI/real-time TRUS Guidance by Focal One
Identifiants
pubmed: 36286396
pii: S2724-6051.22.04853-4
doi: 10.23736/S2724-6051.22.04853-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM