The Glymphatic System: a Potential Key Player in Bacterial Meningitis.
Streptococcus pneumoniae
central nervous system infections
meningitis
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
20 12 2022
20 12 2022
Historique:
entrez:
26
10
2022
pubmed:
27
10
2022
medline:
3
3
2023
Statut:
ppublish
Résumé
The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several neurological disorders. In their article, J. S. Generoso, S. Thorsdottir, A. Collodel, R. R. E. Santo, et al. (mBio 13:e01886-22, 2022, https://doi.org/10.1128/mBio.01886-22) have now associated impaired glymphatic system functionality to neurological sequelae of murine meningitis caused by Streptococcus pneumoniae. Their work provides an initial and important step into the systematic evaluation of a potential impact of glymphatic system functionality on disease severity and sequelae in meningitis.
Identifiants
pubmed: 36286550
doi: 10.1128/mbio.02350-22
pmc: PMC9765658
doi:
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0235022Commentaires et corrections
Type : CommentOn
Références
Neurochem Res. 2015 Dec;40(12):2583-99
pubmed: 25947369
J Exp Med. 2022 Mar 7;219(3):
pubmed: 35212707
Lancet. 2021 Sep 25;398(10306):1171-1183
pubmed: 34303412
Sci Transl Med. 2012 Aug 15;4(147):147ra111
pubmed: 22896675
J Neural Transm (Vienna). 2018 Apr;125(4):673-679
pubmed: 29353355
Nat Commun. 2022 Jul 6;13(1):3897
pubmed: 35794106
Nat Commun. 2018 Nov 19;9(1):4878
pubmed: 30451853
Nature. 2015 Jul 16;523(7560):337-41
pubmed: 26030524
Nat Rev Drug Discov. 2022 Oct;21(10):763-779
pubmed: 35948785
J Cereb Blood Flow Metab. 2017 Jun;37(6):2112-2124
pubmed: 27481936
J Biol Chem. 2005 Apr 8;280(14):13906-12
pubmed: 15695511
J Exp Med. 2022 Aug 1;219(8):
pubmed: 35776089
mBio. 2022 Oct 26;13(5):e0188622
pubmed: 36036510
Front Aging Neurosci. 2022 Apr 25;14:873697
pubmed: 35547631
Science. 2013 Oct 18;342(6156):373-7
pubmed: 24136970
J Cereb Blood Flow Metab. 2022 Aug;42(8):1364-1382
pubmed: 35484910
Acta Neuropathol. 2018 Mar;135(3):387-407
pubmed: 29428972
J Exp Med. 2015 Jun 29;212(7):991-9
pubmed: 26077718
Ann Neurol. 2014 Dec;76(6):845-61
pubmed: 25204284