Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms.

Animals Drosophila melanogaster / metabolism Drosophila Proteins / metabolism Adherens Junctions / metabolism Morphogenesis / physiology Embryonic Development Drosophila / metabolism Guanine Nucleotide Exchange Factors / metabolism Shelterin Complex Telomere-Binding Proteins / metabolism

Journal

Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390

Informations de publication

Date de publication:
01 01 2023
Historique:
pubmed: 27 10 2022
medline: 20 12 2022
entrez: 26 10 2022
Statut: ppublish

Résumé

Embryonic morphogenesis is powered by dramatic changes in cell shape and arrangement driven by the cytoskeleton and its connections to adherens junctions. This requires robust linkage allowing morphogenesis without disrupting tissue integrity. The small GTPase Rap1 is a key regulator of cell adhesion, controlling both cadherin-mediated and integrin-mediated processes. We have defined multiple roles in morphogenesis for one Rap1 effector, Canoe/Afadin, which ensures robust junction-cytoskeletal linkage. We now ask what mechanisms regulate Canoe and other junction-cytoskeletal linkers during 

Identifiants

DOI: 10.1091/mbc.E22-05-0176 PMID: 36287827 PMC: PMC9816648
pubmed: 36287827
doi: 10.1091/mbc.E22-05-0176
pmc: PMC9816648
doi:

Substances chimiques

Drosophila Proteins 0
Guanine Nucleotide Exchange Factors 0
RAP1 protein, Drosophila 0
Shelterin Complex 0
Telomere-Binding Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

ar7

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM118096
Pays : United States
Organisme : NIGMS NIH HHS
ID : F31 GM131521
Pays : United States

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Auteurs

Kia Z Perez-Vale (KZ)

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Kristi D Yow (KD)

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280.

Noah J Gurley (NJ)

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280.

Melissa Greene (M)

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280.

Mark Peifer (M)

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Jonctions adhérentes › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Complexe shelterine › Rap1 regulates apical contractility to allow...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines télomériques › Rap1 regulates apical contractility to allow...