Biokinetics and Internal Dosimetry of Tritiated Steel Particles.

biokinetics dissolution dose coefficients dosimetry rat tritiated steel particles tritium

Journal

Toxics
ISSN: 2305-6304
Titre abrégé: Toxics
Pays: Switzerland
ID NLM: 101639637

Informations de publication

Date de publication:
12 Oct 2022
Historique:
received: 07 09 2022
revised: 05 10 2022
accepted: 06 10 2022
entrez: 26 10 2022
pubmed: 27 10 2022
medline: 27 10 2022
Statut: epublish

Résumé

Decommissioning fission and fusion facilities can result in the production of airborne particles containing tritium that could inadvertently be inhaled by workers directly involved in the operations, and potentially others, resulting in internal exposures to tritium. Of particular interest in this context, given the potentially large masses of material involved, is tritiated steel. The International Commission on Radiological Protection (ICRP) has recommended committed effective dose coefficients for inhalation of some tritiated materials, but not specifically for tritiated steel. The lack of a dose coefficient for tritiated steel is a concern given the potential importance of the material. To address this knowledge gap, a "dissolution" study, in vivo biokinetic study in a rodent model (1 MBq intratracheal instillation, 3-month follow-up) and associated state-of-the-art modelling were undertaken to derive dose coefficients for model tritiated steel particles. A committed effective dose coefficient for the inhalation of 3.3 × 10

Identifiants

pubmed: 36287882
pii: toxics10100602
doi: 10.3390/toxics10100602
pmc: PMC9607624
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Euratom Research and Training Programme
ID : 754586

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Auteurs

Rachel Smith (R)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Michele Ellender (M)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Chang Guo (C)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Derek Hammond (D)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Adam Laycock (A)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Martin O Leonard (MO)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Matthew Wright (M)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Michael Davidson (M)

Radiation Chemicals and Environmental Hazards, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.

Véronique Malard (V)

Biosciences and Biotechnology Institute of Aix-Marseille (BIAM) (Aix-Marseille University, French Alternative Energies and Atomic Energy Commission (CEA), French National Centre for Scientific Research (CNRS)), 13108 Saint Paul-Lez-Durance, France.

Mickaël Payet (M)

Institute for Magnetic Fusion Research (IRFM), French Alternative Energies and Atomic Energy Commission (CEA), 13108 Saint-Paul-lez-Durance, France.

Christian Grisolia (C)

Institute for Magnetic Fusion Research (IRFM), French Alternative Energies and Atomic Energy Commission (CEA), 13108 Saint-Paul-lez-Durance, France.

Eric Blanchardon (E)

Institut de Radioprotection et de Sûreté Nucléaire (IRSN), 92260 Fontenay-aux-Roses, France.

Classifications MeSH