Molecular Characterization of CF33 Canine Cell Line and Evaluation of Its Ability to Respond against Infective Stressors in Sight of Anticancer Approaches.
CF33
Salmonella Typhimurium
canine mammary tumor
gene expression
innate immunity
Journal
Veterinary sciences
ISSN: 2306-7381
Titre abrégé: Vet Sci
Pays: Switzerland
ID NLM: 101680127
Informations de publication
Date de publication:
02 Oct 2022
02 Oct 2022
Historique:
received:
05
09
2022
revised:
27
09
2022
accepted:
27
09
2022
entrez:
26
10
2022
pubmed:
27
10
2022
medline:
27
10
2022
Statut:
epublish
Résumé
Spontaneous mammary tumors are the most frequent neoplasms in bitches and show similarities with human breast cancer in risk factors, clinical course, and histopathology. The poor prognosis of some cancer subtypes, both in human and dog, demands more effective therapeutic approaches. A possible strategy is the new anticancer therapy based on immune response modulation through bacteria or their derivatives on canine mammary carcinoma cell lines. The aim of the present study was to analyze the CF33 cell line in terms of basal expression of immune innate genes, CXCR4 expression, and interaction with infectious stressors. Our results highlight that CF33 maintains gene expression parameters typical of mammary cancer, and provides the basal gene expression of CF33, which is characterized by overexpression of
Identifiants
pubmed: 36288156
pii: vetsci9100543
doi: 10.3390/vetsci9100543
pmc: PMC9610178
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Governo Italiano
ID : IZSPLV 11/20 RC
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