Therapeutic gene editing of T cells to correct CTLA-4 insufficiency.

Humans Mice Animals CTLA-4 Antigen / genetics T-Lymphocytes B7-2 Antigen / genetics Lymphocyte Activation Gene Editing DNA, Complementary Antigens, CD / metabolism B7-1 Antigen / genetics

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
26 10 2022
Historique:
entrez: 26 10 2022
pubmed: 27 10 2022
medline: 29 10 2022
Statut: ppublish

Résumé

Heterozygous mutations in

Identifiants

DOI: 10.1126/scitranslmed.abn5811 PMID: 36288278
pubmed: 36288278
doi: 10.1126/scitranslmed.abn5811
doi:

Substances chimiques

CTLA-4 Antigen 0
B7-2 Antigen 0
DNA, Complementary 0
Antigens, CD 0
B7-1 Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabn5811

Subventions

Organisme : Department of Health
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21738
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21147
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216358/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204798
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N001435/1
Pays : United Kingdom

Auteurs

Thomas Andrew Fox (TA)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
Department of Haematology, University College London NHS Foundation Trust, London, NW1 2BU UK.
UCL Great Ormond Street Institute of Child Health, UCL, London WC1N 1EH, UK.
ORCID: 0000-0002-1163-2295

Benjamin Christopher Houghton (BC)

UCL Great Ormond Street Institute of Child Health, UCL, London WC1N 1EH, UK.
ORCID: 0000-0002-5378-8749

Lina Petersone (L)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0001-8571-9185

Erin Waters (E)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0003-3431-9063

Natalie Mona Edner (NM)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0003-2799-2890

Alex McKenna (A)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.

Olivier Preham (O)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0001-8795-1391

Claudia Hinze (C)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0002-8029-842X

Cayman Williams (C)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0002-0518-1379

Adriana Silva de Albuquerque (AS)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
University College London Hospital, National Institute for Health and Care Research Biomedical Research Centre, London W1T 7DN, UK.
ORCID: 0000-0003-3391-0396

Alan Kennedy (A)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0003-0384-3866

Anne Maria Pesenacker (AM)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0002-7968-0277

Pietro Genovese (P)

Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Boston, MA 02115, USA.
ORCID: 0000-0001-9507-9003

Lucy Sarah Kate Walker (LSK)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0001-5986-5015

Siobhan Oisin Burns (SO)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
Department of Immunology, Royal Free London Hospitals NHS Foundation Trust, London, NW3 2QG, UK.
ORCID: 0000-0002-3356-9506

David Michael Sansom (DM)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
ORCID: 0000-0001-6506-3115

Claire Booth (C)

UCL Great Ormond Street Institute of Child Health, UCL, London WC1N 1EH, UK.
Department of Paediatric Immunology, Great Ormond Street Hospital, London WC1N 3JH, UK.
ORCID: 0000-0002-2626-5037

Emma Catherine Morris (EC)

UCL Institute of Immunity and Transplantation, University College London, London, NW3 2PP, UK.
Department of Haematology, University College London NHS Foundation Trust, London, NW1 2BU UK.
University College London Hospital, National Institute for Health and Care Research Biomedical Research Centre, London W1T 7DN, UK.
Department of Immunology, Royal Free London Hospitals NHS Foundation Trust, London, NW3 2QG, UK.
ORCID: 0000-0003-4834-1130

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Eucaryotes › Animaux › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CTLA-4 › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD86 › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Sondes d'ADN › ADN complémentaire › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Therapeutic gene editing of T cells to correct...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD80 › Therapeutic gene editing of T cells to correct...