Hydrophobicity of Cholic Acid-Derived Amphiphiles Dictates the Antimicrobial Specificity.

Cholic Acid / pharmacology Anti-Bacterial Agents / pharmacology Gram-Positive Bacteria Gram-Negative Bacteria Hydrophobic and Hydrophilic Interactions
antimicrobial selectivity bile acids mycobacteria tuberculosis wound infections

Journal

ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670

Informations de publication

Date de publication:
14 Nov 2022
Historique:
pubmed: 27 10 2022
medline: 16 11 2022
entrez: 26 10 2022
Statut: ppublish

Résumé

The unique structural components of cell membranes of Gram-positive bacteria, Gram-negative bacteria, and mycobacteria provide an excellent therapeutic target for developing highly specific antimicrobials. Here, we report the synthesis of nine cholic acid (CA)-derived amphiphiles, where three hydroxyl groups of CA were tethered to dimethylamino pyridine and the C24-carboxyl group was conjugated with different alkyl chains. Structure-activity investigations revealed that amphiphile

Identifiants

DOI: 10.1021/acsbiomaterials.2c00924 PMID: 36288545
pubmed: 36288545
doi: 10.1021/acsbiomaterials.2c00924
doi:

Substances chimiques

Cholic Acid G1JO7801AE
Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4996-5007

Auteurs

Siddhi Gupta (S)

Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, 3rd Milestone Faridabad-Gurgaon Expressway, NCR Biotech Cluster, Faridabad 121001, Haryana, India.

Amit Arora (A)

Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India.

Varsha Saini (V)

Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, 3rd Milestone Faridabad-Gurgaon Expressway, NCR Biotech Cluster, Faridabad 121001, Haryana, India.

Devashish Mehta (D)

Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, 3rd Milestone Faridabad-Gurgaon Expressway, NCR Biotech Cluster, Faridabad 121001, Haryana, India.
ORCID: 0000-0001-9840-0181

Mehak Zahoor Khan (MZ)

National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.

Deepak K Mishra (DK)

Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, 3rd Milestone Faridabad-Gurgaon Expressway, NCR Biotech Cluster, Faridabad 121001, Haryana, India.

Prabhu Srinivas Yavvari (PS)

Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bypass Road, Bhauri, Bhopal 462066, Madhya Pradesh, India.

Archana Singh (A)

Institute of Genomics and Integrative Biology, South Campus, Mathura Road, New Delhi 110025, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

Sonu Kumar Gupta (SK)

Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad 121001, Haryana, India.

Aasheesh Srivastava (A)

Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bypass Road, Bhauri, Bhopal 462066, Madhya Pradesh, India.
ORCID: 0000-0002-7346-8072

Yashwant Kumar (Y)

Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad 121001, Haryana, India.

Vikas Verma (V)

Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India.

Vinay K Nandicoori (VK)

National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
Centre for Cellular and Molecular Biology, Hyderabad 500007, Telangana, India.

Avinash Bajaj (A)

Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, 3rd Milestone Faridabad-Gurgaon Expressway, NCR Biotech Cluster, Faridabad 121001, Haryana, India.
ORCID: 0000-0002-1333-9316

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholanes › Acides choliques › Acide cholique › Hydrophobicity of Cholic Acid-Derived...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Hydrophobicity of Cholic Acid-Derived...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Hydrophobicity of Cholic Acid-Derived...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Hydrophobicity of Cholic Acid-Derived...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Hydrophobicity of Cholic Acid-Derived...