A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
26 Oct 2022
26 Oct 2022
Historique:
received:
03
05
2022
accepted:
27
09
2022
pmc-release:
26
04
2024
entrez:
26
10
2022
pubmed:
27
10
2022
medline:
27
10
2022
Statut:
aheadofprint
Résumé
Eosinophilic esophagitis (EoE) is a chronic type 2 allergic disease, with esophageal tissue remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to be a central driver of disease, but other inflammatory factors, such as IFNs and TNF superfamily members, have been hypothesized to play a role in disease pathogenesis. We recently found that the cytokine TNFSF14/LIGHT is upregulated in the esophagus of patients with EoE and that LIGHT promotes inflammatory activity in esophageal fibroblasts. However, the global effects of LIGHT on EoE pathogenesis
Identifiants
pubmed: 36288906
pii: jimmunol.2200326
doi: 10.4049/jimmunol.2200326
pmc: PMC10130236
mid: NIHMS1840258
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : K24 AI135034
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114457
Pays : United States
Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.
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