ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
26 10 2022
Historique:
received: 09 09 2020
accepted: 07 10 2022
entrez: 26 10 2022
pubmed: 27 10 2022
medline: 29 10 2022
Statut: epublish

Résumé

Mice display signs of fear when neurons that express cFos during fear conditioning are artificially reactivated. This finding gave rise to the notion that cFos marks neurons that encode specific memories. Here we show that cFos expression patterns in the mouse dentate gyrus (DG) change dramatically from day to day in a water maze spatial learning paradigm, regardless of training level. Optogenetic inhibition of neurons that expressed cFos on the first training day affected performance days later, suggesting that these neurons continue to be important for spatial memory recall. The mechanism preventing repeated cFos expression in DG granule cells involves accumulation of ΔFosB, a long-lived splice variant of FosB. CA1 neurons, in contrast, repeatedly expressed cFos. Thus, cFos-expressing granule cells may encode new features being added to the internal representation during the last training session. This form of timestamping is thought to be required for the formation of episodic memories.

Identifiants

pubmed: 36289226
doi: 10.1038/s41467-022-33947-w
pii: 10.1038/s41467-022-33947-w
pmc: PMC9606265
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6376

Informations de copyright

© 2022. The Author(s).

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Auteurs

Paul J Lamothe-Molina (PJ)

Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. paul@lamothe.de.

Andreas Franzelin (A)

Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Lennart Beck (L)

Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Dong Li (D)

Institute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Lea Auksutat (L)

Research Group Behavioral Biology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Tim Fieblinger (T)

Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Laura Laprell (L)

Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Joachim Alhbeck (J)

Department of Neurophysiology and Pathophysiology, Center for Experimental Medicine (ZEM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Christine E Gee (CE)

Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Matthias Kneussel (M)

Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Andreas K Engel (AK)

Department of Neurophysiology and Pathophysiology, Center for Experimental Medicine (ZEM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Claus C Hilgetag (CC)

Institute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Fabio Morellini (F)

Research Group Behavioral Biology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Thomas G Oertner (TG)

Institute for Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. thomas.oertner@zmnh.uni-hamburg.de.

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