In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia.
Journal
Schizophrenia (Heidelberg, Germany)
ISSN: 2754-6993
Titre abrégé: Schizophrenia (Heidelb)
Pays: Germany
ID NLM: 9918367987006676
Informations de publication
Date de publication:
26 Oct 2022
26 Oct 2022
Historique:
received:
20
02
2022
accepted:
30
09
2022
entrez:
26
10
2022
pubmed:
27
10
2022
medline:
27
10
2022
Statut:
epublish
Résumé
Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in schizophrenia. The role of brain iron in schizophrenia and its potential link to oxidative stress has not been previously examined. In this study, we used 7-Tesla MRI quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and structural T
Identifiants
pubmed: 36289238
doi: 10.1038/s41537-022-00293-1
pii: 10.1038/s41537-022-00293-1
pmc: PMC9605948
doi:
Types de publication
Journal Article
Langues
eng
Pagination
86Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH112748
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : 1 K01 MH115247-01A1
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : 1K24MH110807-01A1
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH125860
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH112748
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH111917
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : K24MH116366
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : 5 U01MH109977
Organisme : Royal Melbourne Hospital (RMH)
ID : GIA-030H2016
Organisme : Royal Melbourne Hospital (RMH)
ID : GIA-030H2016
Organisme : Royal Melbourne Hospital (RMH)
ID : GIA-030H2016
Organisme : Royal Melbourne Hospital (RMH)
ID : GIA-030H2016
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1177370
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1194028
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1196508
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1150083
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : R01AG042512
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : R21DA042271
Informations de copyright
© 2022. The Author(s).
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