Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic
alpha7 nicotinic acetylcholine receptor
bacterial sepsis and meningitis
blood–brain barriers
cytokine-inducible SH2-containing protein
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
22 Sep 2022
22 Sep 2022
Historique:
received:
10
08
2022
revised:
04
09
2022
accepted:
07
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Despite the availability of antibiotics over the last several decades, excessive antibiotic treatments for bacterial sepsis and meningitis (BSM) in children may result in several adverse outcomes. Hematogenous pathogens may directly induce permeability increases in human brain microvascular endothelial cells (HBMECs) and blood-brain barrier (BBB) dysfunctions. Our preliminary studies demonstrated that the alpha7 nicotinic acetylcholine receptor (α7nAChR) played an important role in the pathogenesis of BSM, accompanied by increasing cytokine-inducible SH2-containing protein (CISH) at the transcriptome level, but it has remained unclear how α7nAChR-CISH works mechanistically. The study aims to explore the underlying mechanism of α7nAChR and CISH during
Identifiants
pubmed: 36289622
pii: biomedicines10102358
doi: 10.3390/biomedicines10102358
pmc: PMC9598402
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 81871198 to H.C.
Organisme : National Science Foundation for Young Scientists of China
ID : 81801985 to X.H.
Organisme : Scientific Research Enlightenment Plan of Southern Medical University
ID : B219339044
Références
Cell. 2020 Apr 2;181(1):29-45
pubmed: 32197064
Neuroscience. 2019 Dec 1;422:12-20
pubmed: 31705893
Front Cell Infect Microbiol. 2020 Feb 13;10:47
pubmed: 32117815
Mol Cell Biochem. 2021 Jul;476(7):2869-2876
pubmed: 33740185
Eur J Pharmacol. 2020 Aug 5;880:173189
pubmed: 32417325
Neonatal Netw. 2018 Mar 1;37(2):116-123
pubmed: 29615159
Cytokine. 2021 Feb;138:155377
pubmed: 33348064
J Trop Pediatr. 2015 Feb;61(1):1-13
pubmed: 25604489
Expert Rev Anti Infect Ther. 2020 May;18(5):443-452
pubmed: 32070161
Front Pharmacol. 2020 Nov 30;11:590144
pubmed: 33390965
Front Immunol. 2020 Oct 05;11:551449
pubmed: 33123130
Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418759180
pubmed: 29451405
Am J Perinatol. 2020 Sep;37(S 02):S5-S9
pubmed: 32898875
J Obstet Gynaecol. 2020 Apr;40(3):342-348
pubmed: 31353990
BMC Vet Res. 2020 May 29;16(1):168
pubmed: 32471444
J Clin Invest. 1992 Sep;90(3):897-905
pubmed: 1326000
J Pediatr. 2011 Nov;159(5):720-5
pubmed: 21784435
Brain Sci. 2020 Sep 27;10(10):
pubmed: 32992470
Biochem Biophys Res Commun. 2007 Oct 12;362(1):69-74
pubmed: 17706601
Cancer Lett. 2007 Nov 8;257(1):36-46
pubmed: 17900801
Antioxidants (Basel). 2020 Aug 14;9(8):
pubmed: 32824091
Expert Rev Anti Infect Ther. 2021 Apr;19(4):495-517
pubmed: 33210958
Virulence. 2021 Dec;12(1):360-376
pubmed: 33380272
PLoS One. 2015 May 19;10(5):e0121911
pubmed: 25993608
Microvasc Res. 2020 May;129:103975
pubmed: 31926201
Sci Rep. 2018 Mar 23;8(1):5110
pubmed: 29572553
J Infect Dis. 2001 Apr 1;183(7):1071-8
pubmed: 11237832
Endocrinology. 2009 Apr;150(4):1597-606
pubmed: 19036881
Biomed Res Int. 2020 Sep 14;2020:4616308
pubmed: 33015166
Arch Toxicol. 2021 Feb;95(2):529-540
pubmed: 33159583
Neurosci Lett. 2020 Sep 25;736:135295
pubmed: 32800922
Front Immunol. 2020 Sep 25;11:558341
pubmed: 33072096
Indian J Pediatr. 2001 Jul;68 Suppl 3:S32-9
pubmed: 11980457
Front Microbiol. 2019 Dec 12;10:2810
pubmed: 31921012
Front Immunol. 2021 Oct 14;12:745854
pubmed: 34721415
Eur Spine J. 2018 Mar;27(3):728-736
pubmed: 29214370
PLoS One. 2011;6(9):e25016
pubmed: 21966399
Front Aging Neurosci. 2021 Jan 25;12:606927
pubmed: 33568987
J Immunol. 2014 Jun 15;192(12):5739-48
pubmed: 24835394
Ann Transl Med. 2020 Nov;8(21):1458
pubmed: 33313203
Cell. 2021 Jan 7;184(1):149-168.e17
pubmed: 33278357