The SIRT2 Pathway Is Involved in the Antiproliferative Effect of Flavanones in Human Leukemia Monocytic THP-1 Cells.
SIRT2
cancer
citrus
flavanones
flavonoids
hesperetin
leukemia
naringenin
naringin
neohesperidin
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
24 Sep 2022
24 Sep 2022
Historique:
received:
23
08
2022
revised:
16
09
2022
accepted:
21
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Acute myeloid leukemia (AML) represents the most alarming hematological disease for adults. Several genetic modifications are known to be pivotal in AML; however, SIRT2 over-expression has attracted the scientific community's attention as an unfavorable prognostic marker. The plant kingdom is a treasure trove of bioactive principles, with flavonoids standing out among the others. On this line, the aim of this study was to investigate the anti-leukemic properties of the main flavanones of
Identifiants
pubmed: 36289647
pii: biomedicines10102383
doi: 10.3390/biomedicines10102383
pmc: PMC9598940
pii:
doi:
Types de publication
Journal Article
Langues
eng
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