Vascular Calcification: In Vitro Models under the Magnifying Glass.
VSMCs
anticalcifying agents
in vitro models
vascular calcification
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
06 Oct 2022
06 Oct 2022
Historique:
received:
02
09
2022
revised:
01
10
2022
accepted:
04
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Vascular calcification is a systemic disease contributing to cardiovascular morbidity and mortality. The pathophysiology of vascular calcification involves calcium salt deposition by vascular smooth muscle cells that exhibit an osteoblast-like phenotype. Multiple conditions drive the phenotypic switch and calcium deposition in the vascular wall; however, the exact molecular mechanisms and the connection between vascular smooth muscle cells and other cell types are not fully elucidated. In this hazy landscape, effective treatment options are lacking. Due to the pathophysiological complexity, several research models are available to evaluate different aspects of the calcification process. This review gives an overview of the in vitro cell models used so far to study the molecular processes underlying vascular calcification. In addition, relevant natural and synthetic compounds that exerted anticalcifying properties in in vitro systems are discussed.
Identifiants
pubmed: 36289753
pii: biomedicines10102491
doi: 10.3390/biomedicines10102491
pmc: PMC9599098
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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