Surgical Management of Synucleinopathies.
Parkinson’s disease
deep brain stimulation
dementia with Lewy bodies
focused ultrasound
gene therapy
multiple system atrophy
surgical techniques
synucleinopathies
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
21 Oct 2022
21 Oct 2022
Historique:
received:
20
09
2022
revised:
19
10
2022
accepted:
19
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Synucleinopathies represent a diverse set of pathologies with significant morbidity and mortality. In this review, we highlight the surgical management of three synucleinopathies: Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). After examining underlying molecular mechanisms and the medical management of these diseases, we explore the role of deep brain stimulation (DBS) in the treatment of synuclein pathophysiology. Further, we examine the utility of focused ultrasound (FUS) in the treatment of synucleinopathies such as PD, including its role in blood-brain barrier (BBB) opening for the delivery of novel drug therapeutics and gene therapy vectors. We also discuss other recent advances in the surgical management of MSA and DLB. Together, we give a diverse overview of current techniques in the neurosurgical management of these pathologies.
Identifiants
pubmed: 36289920
pii: biomedicines10102657
doi: 10.3390/biomedicines10102657
pmc: PMC9599076
pii:
doi:
Types de publication
Journal Article
Langues
eng
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