Effect of Unloaded and Curcumin-Loaded Solid Lipid Nanoparticles on Tissue Transglutaminase Isoforms Expression Levels in an Experimental Model of Alzheimer's Disease.
TgCRND8 mice
antioxidants
curcumin
neuroprotection
solid lipid nanoparticles
tissue transglutaminase
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
21 Sep 2022
21 Sep 2022
Historique:
received:
19
07
2022
revised:
08
09
2022
accepted:
14
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disease representing the most prevalent cause of dementia. It is also related to the aberrant amyloid-beta (Aβ) protein deposition in the brain. Since oxidative stress is involved in AD, there is a possible role of antioxidants present in the effected person's diet. Thus, we assessed the effect of the systemic administration of solid lipid nanoparticles (SLNs) to facilitate curcumin (CUR) delivery on TG2 isoform expression levels in Wild Type (WT) and in TgCRND8 (Tg) mice. An experimental model of AD, which expresses two mutated human amyloid precursor protein (APP) genes, was used. Behavioral studies were also performed to evaluate the improvement of cognitive performance and memory function induced by all treatments. The expression levels of Bcl-2, Cyclin-D
Identifiants
pubmed: 36290586
pii: antiox11101863
doi: 10.3390/antiox11101863
pmc: PMC9599010
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : "NanoRET- Patologie neurodegenerative retiniche: nuovi approcci farmacologici e nanotecnologici".
ID : 57722172128
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