Astaxanthin Is Able to Prevent Alcohol-Induced Dysfunction of Liver Mitochondria.
astaxanthin (AX)
chronic ethanol intoxication
rat liver mitochondria (RLM)
the activity of respiratory chain complexes
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
12 Oct 2022
12 Oct 2022
Historique:
received:
05
09
2022
revised:
30
09
2022
accepted:
11
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
The search for new targets for the pathological action of ethanol remains an urgent task of biomedicine. Since degenerative changes in the liver are associated with the development of oxidative stress, antioxidants are promising agents for the treatment of alcohol-related diseases. In this work, we studied the ability of the carotenoid antioxidant, astaxanthin (AX), to prevent ethanol-induced changes in the liver of rats. It was shown that AX is able to protect the structure of mitochondria from degenerative changes caused by ethanol to improve mitochondrial functions. AX positively influences the activity and expression of proteins of the mitochondrial respiratory chain complexes and ATPase. In addition, a protective effect of AX on the rate and activity of mitochondrial respiration was demonstrated in the work. Thus, studies have shown that AX is involved in protective mechanisms in response to ethanol-induced mitochondrial dysfunction.
Identifiants
pubmed: 36290741
pii: antiox11102019
doi: 10.3390/antiox11102019
pmc: PMC9598831
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Foundation for Basic Research
ID : 20-04-00131
Organisme : Russian Foundation for Basic Research
ID : 20-015-00072
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