Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets?
competitive endogenous RNAs
diabetes
diabetic retinopathy
epigenetics
gene expression deregulation
long non-coding RNAs
non-coding RNAs
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
12 Oct 2022
12 Oct 2022
Historique:
received:
17
09
2022
revised:
05
10
2022
accepted:
09
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
The growing incidence of diabetes mellitus worldwide implies the increasing prevalence of several related macro- (e.g., hypertension and atherosclerosis) and micro-vascular (e.g., nephropathy and retinopathy) complications. Notably, diabetic retinopathy (DR) is the leading cause of blindness in older diabetic patients and can occur with different degrees of severity. Chronic hyperglycemia is the main determinant of the functional damage of retinal cells. The oxidative stress, inflammatory factors and vascular endothelial growth factor signaling have been widely reported as contributors of DR onset and progression, and an emerging role has been described for different classes of non-coding RNA, including several long non-coding RNAs (lncRNAs). Here, we report the main results of all research articles (i.e., 150) listed on PubMed database from 2014 to 2022 regarding the putative role of lncRNAs in DR, including small nucleolar RNA host genes (SNHGs). Particularly, in this review we describe all lncRNAs and SNHGs with altered expression in DR and related contexts, discussing their association with DR outcomes, their mechanism of action related to DR, the molecular/functional effects, as well as the biological and experimental contexts. Thus, herein we provide an overview of the current state of knowledge regarding the putative involvement of 50 lncRNAs and SNHGs in the pathogenesis of DR, highlighting their potential as therapeutic targets or biomarkers for improving the clinical management of DR.
Identifiants
pubmed: 36290744
pii: antiox11102021
doi: 10.3390/antiox11102021
pmc: PMC9598326
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : the Study of Diabetes (EFSD), EFSD/Boehringer Ingelheim European Research Programme, IDF SHARID in Microvascular Complications of Diabetes to A.C.
ID : PON Ricerca e Innovazione 2014-2020, PON Ars01_01270
Références
Cancers (Basel). 2020 May 09;12(5):
pubmed: 32397382
Cell Death Dis. 2015 Aug 20;6:e1858
pubmed: 26291312
Int Ophthalmol. 2020 May;40(5):1123-1133
pubmed: 31912402
Endocr J. 2019 Nov 28;66(11):1011-1016
pubmed: 31391356
Dis Markers. 2022 Feb 9;2022:8859677
pubmed: 35186169
Diabetes Metab J. 2018 Oct;42(5):364-376
pubmed: 30362302
Diabetologia. 2019 Mar;62(3):517-530
pubmed: 30612136
PLoS One. 2016 Dec 9;11(12):e0164941
pubmed: 27935942
Inflamm Res. 2018 Dec;67(11-12):913-925
pubmed: 30151700
Diabetes. 2021 Jan;70(1):227-239
pubmed: 33051272
Med Sci Monit. 2022 Jan 10;28:e932996
pubmed: 35001073
Int J Clin Exp Pathol. 2019 Jun 01;12(6):2022-2033
pubmed: 31934024
Biomed Pharmacother. 2020 May;125:109959
pubmed: 32106367
Cancer Manag Res. 2020 Oct 15;12:10181-10198
pubmed: 33116873
Eur Rev Med Pharmacol Sci. 2018 Apr;22(8):2282-2286
pubmed: 29762830
Arch Physiol Biochem. 2022 Jun;128(3):637-642
pubmed: 32125187
Curr Pharm Des. 2021;27(27):3047-3060
pubmed: 33530902
Exp Mol Pathol. 2019 Apr;107:102-109
pubmed: 30529346
Life Sci. 2021 May 1;272:119232
pubmed: 33600866
RNA Biol. 2017 Dec 2;14(12):1705-1714
pubmed: 28837398
Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):470-480
pubmed: 28122089
DNA Cell Biol. 2017 Jun;36(6):475-481
pubmed: 28418724
Exp Eye Res. 2021 Jun;207:108561
pubmed: 33812869
Adv Exp Med Biol. 2017;1008:47-74
pubmed: 28815536
Mol Med Rep. 2020 Aug;22(2):1072-1080
pubmed: 32467994
Biochem Biophys Res Commun. 2016 Oct 14;479(2):198-203
pubmed: 27616193
Int J Med Sci. 2020 Feb 17;17(5):591-598
pubmed: 32210708
Brief Bioinform. 2019 Sep 27;20(5):1781-1794
pubmed: 29939215
Am J Physiol Cell Physiol. 2020 Feb 1;318(2):C346-C359
pubmed: 31693400
Stem Cell Rev Rep. 2018 Dec;14(6):823-836
pubmed: 29980981
Int J Mol Sci. 2019 Dec 13;20(24):
pubmed: 31847264
Biosci Rep. 2017 Apr 28;37(2):
pubmed: 28246353
Circ Res. 2015 Mar 27;116(7):1143-56
pubmed: 25587098
Front Pharmacol. 2020 Jan 31;10:1703
pubmed: 32082175
Exp Ther Med. 2018 Sep;16(3):2337-2342
pubmed: 30186476
Mol Med Rep. 2018 Jul;18(1):16-24
pubmed: 29749509
Bioengineered. 2022 May;13(5):12661-12672
pubmed: 35599572
J Diabetes Investig. 2022 Mar;13(3):443-452
pubmed: 34935307
Acta Diabetol. 2020 Sep;57(9):1111-1116
pubmed: 32447557
PeerJ. 2021 Jul 23;9:e11817
pubmed: 34386303
Cells. 2021 Apr 23;10(5):
pubmed: 33922686
Biosci Biotechnol Biochem. 2019 May;83(5):869-875
pubmed: 30700211
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5558-5563
pubmed: 30480744
Inflamm Res. 2020 Mar;69(3):255-265
pubmed: 31953562
EMBO J. 2013 Dec 11;32(24):3145-60
pubmed: 24240175
Pathol Res Pract. 2022 Apr;232:153807
pubmed: 35202907
IUBMB Life. 2019 Mar;71(3):310-320
pubmed: 30468285
Med Sci Monit. 2019 Nov 11;25:8509-8514
pubmed: 31711064
FEBS J. 2019 Jun;286(12):2261-2272
pubmed: 30927500
Invest Ophthalmol Vis Sci. 2012 Jul 24;53(8):4881-8
pubmed: 22743328
Biomed Pharmacother. 2020 Apr;124:109699
pubmed: 31986419
Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):7732-7739
pubmed: 31599399
Genes Dev. 2016 Jan 1;30(1):34-51
pubmed: 26701265
PLoS Genet. 2010 Dec 02;6(12):e1001233
pubmed: 21151960
Circ Res. 2014 Apr 25;114(9):1389-97
pubmed: 24602777
Cells. 2021 Sep 13;10(9):
pubmed: 34572058
Epigenetics. 2013 Sep;8(9):990-7
pubmed: 23975186
Noncoding RNA. 2020 Oct 30;6(4):
pubmed: 33143162
Cell Mol Neurobiol. 2017 Mar;37(2):361-369
pubmed: 27193103
Endocr Dev. 2009;14:1-9
pubmed: 19293570
Cancer Sci. 2006 Nov;97(11):1147-54
pubmed: 16965397
Mol Biol Rep. 2020 Aug;47(8):6357-6374
pubmed: 32743775
J Cell Physiol. 2020 Feb;235(2):1309-1320
pubmed: 31313295
J Cell Biochem. 2020 Jun;121(5-6):3235-3247
pubmed: 31943306
Cancer Cell Int. 2021 Oct 24;21(1):558
pubmed: 34689775
JCI Insight. 2021 Nov 8;6(21):
pubmed: 34582376
Genome Biol. 2013;14(9):R104
pubmed: 24070194
Genes Cells. 2014 Sep;19(9):704-21
pubmed: 25145264
J Cell Physiol. 2020 Nov;235(11):8724-8735
pubmed: 32324260
Noncoding RNA. 2020 Jun 03;6(2):
pubmed: 32503170
Neurocrit Care. 2022 Feb;36(1):106-115
pubmed: 34286462
J Cell Physiol. 2019 Aug;234(10):17269-17279
pubmed: 30784065
Circ Res. 2014 Sep 26;115(8):709-20
pubmed: 25091710
Arch Physiol Biochem. 2021 Oct 21;:1-9
pubmed: 34674599
J Clin Lab Anal. 2022 Feb;36(2):e24215
pubmed: 35028972
Elife. 2014 Sep 16;3:e03523
pubmed: 25233276
Nature. 1991 Jan 3;349(6304):38-44
pubmed: 1985261
Diabetol Metab Syndr. 2022 May 15;14(1):73
pubmed: 35570299
Sci Rep. 2018 Apr 25;8(1):6526
pubmed: 29695738
Int J Ophthalmol. 2020 Feb 18;13(2):213-219
pubmed: 32090029
J Mol Endocrinol. 2012 Apr 02;48(3):R45-53
pubmed: 22393162
Int J Mol Sci. 2018 Jun 20;19(6):
pubmed: 29925789
Gene. 2018 Apr 5;649:32-39
pubmed: 29391273
Bioessays. 2010 Jun;32(6):473-80
pubmed: 20486133
Cancer Lett. 2019 May 28;450:14-21
pubmed: 30807784
Biochem Biophys Res Commun. 2019 Jun 25;514(2):503-509
pubmed: 31056258
Int J Biol Sci. 2017 Sep 5;13(9):1180-1191
pubmed: 29104509
Mol Cells. 2016 May 31;39(5):367-74
pubmed: 27137091
J Hum Genet. 2006;51(12):1087-1099
pubmed: 17066261
Biochem Biophys Res Commun. 2016 Feb 26;471(1):135-41
pubmed: 26845358
Neural Regen Res. 2022 Jun;17(6):1364-1368
pubmed: 34782583
Am J Pathol. 2020 Sep;190(9):1813-1822
pubmed: 32473920
Int J Mol Sci. 2018 Feb 14;19(2):
pubmed: 29443889
Nat Rev Cancer. 2012 Jan 19;12(2):84-8
pubmed: 22257949
Chin J Cancer. 2015 Aug 15;34(10):459-67
pubmed: 26275421
Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):941-51
pubmed: 24436191
Graefes Arch Clin Exp Ophthalmol. 2019 Sep;257(9):1897-1913
pubmed: 31327036
Free Radic Biol Med. 2021 Jun;169:361-381
pubmed: 33762162
Cells. 2021 Nov 23;10(12):
pubmed: 34943778
J Mol Neurosci. 2022 Feb;72(2):187-200
pubmed: 34415549
J Cell Biochem. 2018 Jan;119(1):817-823
pubmed: 28657668
Biomed Pharmacother. 2018 May;101:510-527
pubmed: 29505922
J Am Coll Cardiol. 2015 Nov 3;66(18):2005-2015
pubmed: 26516004
Can J Physiol Pharmacol. 2021 Nov;99(11):1207-1216
pubmed: 34197720
Annu Rev Genet. 2018 Nov 23;52:535-566
pubmed: 30256677
Onco Targets Ther. 2020 Aug 05;13:7699-7717
pubmed: 32848414
Clin Sci (Lond). 2020 Sep 18;134(17):2419-2434
pubmed: 32812634
EMBO J. 2021 Aug 2;40(15):e107134
pubmed: 34180064
Front Genet. 2014 Mar 25;5:57
pubmed: 24723937
Theranostics. 2018 Mar 28;8(9):2496-2507
pubmed: 29721095
Mol Cancer. 2020 Feb 4;19(1):22
pubmed: 32019587
J Inflamm Res. 2021 Apr 20;14:1563-1573
pubmed: 33907437
Front Endocrinol (Lausanne). 2021 Mar 19;12:602597
pubmed: 33815273
Biosci Rep. 2019 May 15;39(5):
pubmed: 30988072
Clin Oral Investig. 2022 Feb;26(2):1121-1135
pubmed: 34821979
BMC Dev Biol. 2010 May 11;10:49
pubmed: 20459797
Cell Death Dis. 2014 Oct 30;5:e1506
pubmed: 25356875
Am J Transl Res. 2019 Apr 15;11(4):2413-2421
pubmed: 31105847
Diab Vasc Dis Res. 2018 May;15(3):204-213
pubmed: 29383970
IUBMB Life. 2021 Jun;73(6):825-842
pubmed: 33938625
IUBMB Life. 2019 Oct;71(10):1611-1618
pubmed: 31317640
Cell Death Dis. 2016 Jun 02;7(6):e2248
pubmed: 27253412
Exp Ther Med. 2020 Dec;20(6):246
pubmed: 33178344
Can J Physiol Pharmacol. 2021 Nov;99(11):1175-1183
pubmed: 34081870
Kaohsiung J Med Sci. 2021 Feb;37(2):101-110
pubmed: 33022863
Diabetes Care. 2012 Mar;35(3):556-64
pubmed: 22301125
Diabetes. 2013 Jul;62(7):2559-68
pubmed: 23423566
Biomed Pharmacother. 2021 Oct;142:112051
pubmed: 34426254
EMBO Mol Med. 2016 Mar 31;8(4):346-62
pubmed: 26964565
Med Sci Monit. 2019 Apr 18;25:2845-2851
pubmed: 30996220
Arch Physiol Biochem. 2021 Apr 6;:1-6
pubmed: 33822671
Eur Rev Med Pharmacol Sci. 2018 May;22(10):2941-2948
pubmed: 29863235
Transl Cancer Res. 2021 Jun;10(6):3140-3157
pubmed: 35116622
J Stroke Cerebrovasc Dis. 2018 Feb;27(2):326-337
pubmed: 29030044
Horm Metab Res. 2022 Feb;54(2):119-125
pubmed: 35130573
Diabetes Metab Syndr Obes. 2021 Oct 13;14:4233-4240
pubmed: 34675574
Bioengineered. 2021 Dec;12(2):11872-11884
pubmed: 34978518
Hum Genomics. 2018 Aug 23;12(1):41
pubmed: 30139387
Exp Ther Med. 2019 May;17(5):4132-4138
pubmed: 31007747
Acta Diabetol. 2020 Apr;57(4):409-418
pubmed: 31691869
Front Biosci (Landmark Ed). 2018 Jan 1;23(4):614-625
pubmed: 28930564
PLoS One. 2014 Nov 03;9(11):e111715
pubmed: 25364816
Exp Ther Med. 2021 Nov;22(5):1274
pubmed: 34594411
Biomolecules. 2020 May 18;10(5):
pubmed: 32443616
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 May;34(3):273-8
pubmed: 12019437
Nature. 2012 Jun 10;486(7403):353-60
pubmed: 22722193
Oncotarget. 2017 Jan 3;8(1):1429-1437
pubmed: 27903964
Nature. 2013 Oct 17;502(7471):333-339
pubmed: 24132290
Bull Cancer. 2019 Dec;106(12):1152-1159
pubmed: 31753509
Redox Rep. 2022 Dec;27(1):70-78
pubmed: 35285425
Eur Rev Med Pharmacol Sci. 2019 Nov;23(21):9163-9170
pubmed: 31773666
Int J Mol Sci. 2021 Sep 28;22(19):
pubmed: 34638838
Cell Physiol Biochem. 2017;42(1):295-305
pubmed: 28535504
Antioxid Redox Signal. 2012 Aug 1;17(3):492-504
pubmed: 22229649
Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E598-E608
pubmed: 33284093
Biosci Rep. 2020 Jul 31;40(7):
pubmed: 32519748
J Cell Physiol. 2020 Dec;235(12):9361-9369
pubmed: 32356340
Asia Pac J Ophthalmol (Phila). 2018 Jan-Feb;7(1):28-35
pubmed: 29473719
Mol Biotechnol. 2022 Feb;64(2):171-177
pubmed: 34554391
Crit Rev Biotechnol. 2014 Jun;34(2):134-43
pubmed: 23113554
Invest Ophthalmol Vis Sci. 2013 Jan 14;54(1):244-50
pubmed: 23221071
In Vitro Cell Dev Biol Anim. 2016 Apr;52(4):419-26
pubmed: 26822433
Mol Psychiatry. 2014 Apr;19(4):486-94
pubmed: 23628989
Can J Physiol Pharmacol. 2020 Apr;98(4):219-227
pubmed: 31689123
Biochem Biophys Res Commun. 2017 Jan 22;482(4):777-783
pubmed: 27876564
Cancer Biother Radiopharm. 2020 May;35(4):307-312
pubmed: 32191497
Eur Rev Med Pharmacol Sci. 2020 Jun;24(11):5871-5877
pubmed: 32572899
Front Oncol. 2021 Jan 14;10:622294
pubmed: 33520729
PLoS Genet. 2016 Apr 07;12(4):e1005893
pubmed: 27055116
Exp Eye Res. 2022 May;218:108984
pubmed: 35202706
Exp Eye Res. 2021 Jan;202:108300
pubmed: 33065089
Cell Mol Life Sci. 2020 Oct;77(19):3769-3779
pubmed: 32219465
Genet Mol Biol. 2019 Jul-Sep;42(3):509-518
pubmed: 31188931
Int J Biochem Cell Biol. 2019 Sep;114:105574
pubmed: 31344482
Acta Diabetol. 2021 Jun;58(6):759-769
pubmed: 33576890
J Cell Mol Med. 2015 Jun;19(6):1418-25
pubmed: 25787249
BMC Med Genomics. 2019 Oct 15;12(1):134
pubmed: 31615521
Bosn J Basic Med Sci. 2020 Aug 03;20(3):365-371
pubmed: 31999937
J Diabetes Investig. 2021 Nov;12(11):1948-1957
pubmed: 34137197
Hum Mol Genet. 2012 Jan 1;21(1):10-25
pubmed: 21920939
Mol Ther Nucleic Acids. 2021 Feb 04;24:512-527
pubmed: 33898104
Folia Histochem Cytobiol. 2012 Jul 05;50(2):171-9
pubmed: 22763974
Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):20
pubmed: 33724292
EBioMedicine. 2022 Mar;77:103857
pubmed: 35172268
Cancers (Basel). 2020 Oct 31;12(11):
pubmed: 33142861
Autoimmunity. 2021 Dec;54(8):504-513
pubmed: 34498499
Biomolecules. 2021 Oct 29;11(11):
pubmed: 34827600
Med Sci Monit. 2018 Dec 31;24:9497-9503
pubmed: 30595603
Exp Eye Res. 2021 Jun;207:108585
pubmed: 33887222
Diabetologia. 2015 Mar;58(3):443-55
pubmed: 25481708