Morbidity and Mortality of Neutropenic Patients in Visceral Surgery: A Narrative Review.
agranulocytosis
hematologic diseases
leukocyte disorders
leukopenia
outcome
postoperative complications
surgery
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
21 10 2022
21 10 2022
Historique:
received:
26
09
2022
revised:
16
10
2022
accepted:
18
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Leukocytes are essential for the function of the immune system and cell-cell interaction in the human body, but hematological diseases as well as chemotherapeutic treatments due to cancer lead to occasionally or even permanent leukocyte deficiency. Normally, more than 50% of leukocytes are neutrophilic granulocytes, and leukopenia is, therefore, mostly characterized by a decrease in neutrophilic granulocytes. The consequence of neutropenia is increased susceptibility to infection, but also healing disorders are suggestable due to the disturbed cell-cell interaction. While there is no surgical treatment for leucocyte disorders, patients suffering from neutropenia are sometimes in need of surgery for other reasons. Less is known about the morbidity and mortality of this patients, which is why this narrative review critically summarizes the results of recent research in this particular field. The results of this review suggest that neutropenic patients in need of emergency surgery have a higher mortality risk compared to non-neutropenic patients. In contrast, in elective surgery, there was not a clear tendency for a higher mortality risk of neutropenic patients. The role of neutrophilic granulocytes in inflammation and immunity in surgical patients is emphasized by the results, but most of the evaluated studies showed methodological flaws due to small sample sizes or risk of bias. Further research has to evaluate the risk for postoperative complications, particularly of infectious complications such as surgical site infections, in neutropenic patients undergoing elective surgery, and should address the role of neutrophilic function in postoperative morbidity and mortality.
Identifiants
pubmed: 36291181
pii: cells11203314
doi: 10.3390/cells11203314
pmc: PMC9600855
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Ann Clin Lab Sci. 2004 Spring;34(2):131-7
pubmed: 15228223
Ann Hematol. 2014 Jul;93(7):1083-95
pubmed: 24777705
Haematologica. 2014 Jul;99(7):1130-3
pubmed: 24986874
Curr Opin Gastroenterol. 2006 Jan;22(1):44-7
pubmed: 16319675
J Surg Res. 2015 Feb;193(2):868-73
pubmed: 25439507
Adv Exp Med Biol. 2017;1003:3-14
pubmed: 28667551
Nat Rev Immunol. 2017 Nov;17(11):679-690
pubmed: 28757604
J Surg Oncol. 2010 Sep 15;102(4):321-4
pubmed: 20589705
Tech Coloproctol. 2021 Mar;25(3):267-278
pubmed: 33386511
Rev Invest Clin. 2021 May 04;73(4):251-258
pubmed: 33944860
J Trauma Acute Care Surg. 2015 Sep;79(3):437-43
pubmed: 26307878
Diagnostics (Basel). 2021 Nov 13;11(11):
pubmed: 34829446
Med Hypotheses. 1978 May-Jun;4(3):193-207
pubmed: 672709
Ann Surg. 2004 Jul;240(1):68-75
pubmed: 15213620
Ann Biol Clin (Paris). 2021 Feb 1;79(1):17-27
pubmed: 33563585
J Anesth. 2010 Apr;24(2):268-71
pubmed: 20094735
Chirurg. 1998 Apr;69(4):443-9
pubmed: 9612631
Dan Med Bull. 2003 May;50(2):139-60
pubmed: 12812138
Pol Przegl Chir. 2018 Dec 10;91(1):22-28
pubmed: 30919812
Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):89-102
pubmed: 31202687
Nat Immunol. 2019 Jul;20(7):783-792
pubmed: 31213714
Cancer. 1990 Feb 15;65(4):1041-7
pubmed: 2404562
Eur J Haematol. 2005 Jul;75(1):1-13
pubmed: 15946304
Trends Immunol. 2019 Jul;40(7):584-597
pubmed: 31153737
Ann Surg. 2004 Jan;239(1):75-81
pubmed: 14685103
J Trauma. 1996 May;40(5):727-32
pubmed: 8614070
J Gastrointest Surg. 2021 Dec;25(12):3258-3264
pubmed: 34506017
Cancer. 2004 Jan 15;100(2):228-37
pubmed: 14716755
Trends Immunol. 2019 Jul;40(7):565-583
pubmed: 31160207
J Vasc Interv Radiol. 2014 Mar;25(3):419-23
pubmed: 24581465
Ann Coloproctol. 2020 Jun;36(3):178-185
pubmed: 32674547
Am J Infect Control. 2016 Apr 1;44(4):450-4
pubmed: 27038393
Infect Control Hosp Epidemiol. 1992 Oct;13(10):606-8
pubmed: 1334988
J Gastrointest Surg. 2020 Mar;24(3):659-670
pubmed: 30937711
Expert Rev Hematol. 2017 Feb;10(2):169-174
pubmed: 28075196
Clin Lab Med. 1993 Dec;13(4):879-94
pubmed: 8313687
J Hosp Infect. 2008 Nov;70 Suppl 2:3-10
pubmed: 19022115
J Gastrointest Oncol. 2018 Feb;9(1):17-23
pubmed: 29564167
Eur Radiol. 2002 May;12(5):1179-87
pubmed: 11976865
Res Integr Peer Rev. 2019 Mar 26;4:5
pubmed: 30962953
Clin Infect Dis. 1993 Sep;17(3):484-90
pubmed: 8218694
Cancer. 1992 Jan 1;69(1):17-23
pubmed: 1727660
World J Emerg Surg. 2017 Aug 7;12:38
pubmed: 28794797
J Leukoc Biol. 2020 Jul;108(1):377-396
pubmed: 32202340
Ann Intensive Care. 2016 Dec;6(1):112
pubmed: 27858375
Surg Infect (Larchmt). 2017 May/Jun;18(4):440-446
pubmed: 28402740
Esophagus. 2021 Jan;18(1):41-48
pubmed: 32514753
Ann Surg Oncol. 2012 Jan;19(1):11-8
pubmed: 21761105
Pediatr Blood Cancer. 2021 Oct;68(10):e29105
pubmed: 34151520
Anticancer Res. 2015 Sep;35(9):4889-95
pubmed: 26254384
Blood. 2014 Aug 21;124(8):1251-8; quiz 1378
pubmed: 24869938
Ann Intensive Care. 2018 Apr 19;8(1):47
pubmed: 29675758
Cell. 2020 Nov 25;183(5):1282-1297.e18
pubmed: 33098771
Arch Surg. 1990 Sep;125(9):1119-27
pubmed: 2400304
Can J Microbiol. 2018 Jul;64(7):439-453
pubmed: 29586541
Expert Rev Anti Infect Ther. 2019 Dec;17(12):983-995
pubmed: 30686067
Crit Care Nurs Clin North Am. 2017 Mar;29(1):51-65
pubmed: 28160957
Immunol Rev. 2016 Sep;273(1):357-70
pubmed: 27558346
Radiother Oncol. 2009 Nov;93(2):293-7
pubmed: 19748694
Leuk Lymphoma. 2017 Oct;58(10):2395-2402
pubmed: 28278710
Dtsch Med Wochenschr. 2017 Nov;142(23):1744-1749
pubmed: 29145679
Am J Gastroenterol. 2008 Sep;103(9):2373-81
pubmed: 18616660
Am J Surg. 2020 Jul;220(1):132-134
pubmed: 31703837
Case Rep Otolaryngol. 2018 Apr 19;2018:7426819
pubmed: 29850337