Mining the Immunopeptidome for Antigenic Peptides in Cancer.
PTM
cancer vaccine
immunopeptidome
immunotherapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Oct 2022
11 Oct 2022
Historique:
received:
16
08
2022
revised:
05
10
2022
accepted:
08
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Although harnessing the immune system for cancer therapy has shown success, response to immunotherapy has been limited. The immunopeptidome of cancer cells presents an opportunity to discover novel antigens for immunotherapy applications. These neoantigens bind to MHC class I and class II molecules. Remarkably, the immunopeptidome encompasses protein post-translation modifications (PTMs) that may not be evident from genome or transcriptome profiling. A case in point is citrullination, which has been demonstrated to induce a strong immune response. In this review, we cover how the immunopeptidome, with a special focus on PTMs, can be utilized to identify cancer-specific antigens for immunotherapeutic applications.
Identifiants
pubmed: 36291752
pii: cancers14204968
doi: 10.3390/cancers14204968
pmc: PMC9599891
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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