The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research.
FLASH radiotherapy
high dose rate radiotherapy
microbeam radiotherapy (MRT)
synchrotron
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
20 Oct 2022
20 Oct 2022
Historique:
received:
06
09
2022
revised:
04
10
2022
accepted:
16
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
High dose rate radiotherapies such as FLASH and microbeam radiotherapy (MRT) both have developed to the stage of first veterinary studies within the last decade. With the development of a new research tool for high dose rate radiotherapy at the end station P61A of the synchrotron beamline P61 on the DESY campus in Hamburg, we increased the research capacity in this field to speed up the translation of the radiotherapy techniques which are still experimental, from bench to bedside. At P61, dose rates of several hundred Gy/s can be delivered. Compared to dedicated biomedical beamlines, the beam width available for MRT experiments is a very restrictive factor. We developed two model systems specifically to suit these specific technical parameters and tested them in a first set of experiments.
Identifiants
pubmed: 36291920
pii: cancers14205137
doi: 10.3390/cancers14205137
pmc: PMC9600877
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : German Research Foundation (DFG)
ID : SCHU 2589/7-1
Organisme : German Academic Exchange Service
ID : DAAD PPP 57444927
Organisme : HEREON travel support
ID : no number
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