Placenta, the Key Witness of COVID-19 Infection in Premature Births.
COVID-19
SARS-CoV-2
placenta
preterm birth
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
26 Sep 2022
26 Sep 2022
Historique:
received:
31
08
2022
revised:
22
09
2022
accepted:
23
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Adverse perinatal outcomes, such as increased risks of pre-eclampsia, miscarriage, premature birth, and stillbirth have been reported in SARS-CoV-2 infection. For a better understanding of COVID-19 complications in pregnancy, histopathological changes in the placenta, which is the interface between mother and foetus, could be the place to look at. The aim of this study was to determine placental histopathological changes and their role in preterm birth in pregnant women with SARS-CoV-2 infection. We performed a prospective, observational study in a COVID-only hospital, which included 39 pregnant women with SARS-CoV-2 infection and preterm birth compared with a control group of 39 women COVID-19 negative with preterm birth and a placental pathology exam available. The microscopic examination of all placentas revealed placental infarction (64.1% vs. 30.8%), decidual arteriopathy (66.7% vs. 23.1%), intervillous thrombi (53.8% vs. 38.5%), perivillous fibrin deposits (59% vs. 46.2%), inflammatory infiltrate (69.2% vs. 46.2%), chorangiosis (17.9% vs. 10.3%), and accelerated maturation of the villi (23.1% vs. 28.2%).
Identifiants
pubmed: 36292012
pii: diagnostics12102323
doi: 10.3390/diagnostics12102323
pmc: PMC9600231
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Mod Pathol. 2020 Nov;33(11):2092-2103
pubmed: 32741970
Sci Rep. 2021 Jul 6;11(1):13898
pubmed: 34230507
Ultrasound Obstet Gynecol. 2020 May;55(5):586-592
pubmed: 32180292
Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:194-204
pubmed: 33246205
Clin Infect Dis. 2020 Jul 28;71(15):844-846
pubmed: 32119083
Am J Obstet Gynecol. 2021 Apr;224(4):382.e1-382.e18
pubmed: 33091406
Int J Mol Sci. 2021 May 28;22(11):
pubmed: 34071527
Circ Res. 2016 Apr 15;118(8):1313-26
pubmed: 27081112
Am J Clin Pathol. 2020 Jun 8;154(1):23-32
pubmed: 32441303
Postgrad Med J. 2000 Nov;76(901):683-9
pubmed: 11060141
APMIS. 2018 Jul;126(7):589-601
pubmed: 29271494
Pregnancy Hypertens. 2018 Apr;12:6-10
pubmed: 29674201
Am J Obstet Gynecol. 2021 Mar;224(3):298.e1-298.e8
pubmed: 32853537
APMIS. 2018 Jul;126(7):551-560
pubmed: 30129127
Elife. 2020 Jul 14;9:
pubmed: 32662421
Curr Probl Cardiol. 2020 Aug;45(8):100618
pubmed: 32439197
JAMA. 2022 Feb 22;327(8):748-759
pubmed: 35129581
Placenta. 2017 Apr;52:106-113
pubmed: 28454692
Eur J Clin Microbiol Infect Dis. 2020 Jul;39(7):1209-1220
pubmed: 32328850
Arch Pathol Lab Med. 2021 Jun 1;145(6):648-656
pubmed: 33596304
Am J Obstet Gynecol. 2020 Aug;223(2):275-278
pubmed: 32405074
J Perinat Med. 2020 Nov 26;48(9):950-958
pubmed: 32975205
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727-11734
pubmed: 32376634
JAMA. 2020 Jun 2;323(21):2198-2200
pubmed: 32352491
Am J Obstet Gynecol MFM. 2020 May;2(2):100107
pubmed: 32292902
Hum Pathol. 2021 Mar;109:69-79
pubmed: 33321162
Diagnostics (Basel). 2021 Jan 08;11(1):
pubmed: 33435547
Am J Obstet Gynecol MFM. 2021 Jul;3(4):100329
pubmed: 33621713
Pediatr Dev Pathol. 2020 Aug;23(4):274-284
pubmed: 32146874
Am J Obstet Gynecol. 2005 Feb;192(2):452-7
pubmed: 15695986
Arch Pathol Lab Med. 2016 Jul;140(7):698-713
pubmed: 27223167
Placenta. 2020 Nov;101:13-29
pubmed: 32911234
J Matern Fetal Neonatal Med. 2022 Aug;35(15):3002-3003
pubmed: 32669006
J Mol Histol. 2021 Jun;52(3):427-435
pubmed: 33871721