Differentially Methylated DNA Regions and Left Ventricular Hypertrophy in African Americans: A HyperGEN Study.
DMR
DNA methylation
EWAS
epigenetics
left ventricular hypertrophy
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
22 Sep 2022
22 Sep 2022
Historique:
received:
26
06
2022
revised:
15
09
2022
accepted:
20
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Left ventricular (LV) hypertrophy (LVH) is an independent risk factor for cardiovascular disease, and African Americans experience a disparate high risk of LVH. Genetic studies have identified potential candidate genes and variants related to the condition. Epigenetic modifications may continue to help unravel disease mechanisms. We used methylation and echocardiography data from 636 African Americans selected from the Hypertension Genetic Epidemiology Network (HyperGEN) to identify differentially methylated regions (DMRs) associated with LVH. DNA extracted from whole blood was assayed on Illumina Methyl450 arrays. We fit linear mixed models to examine associations between co-methylated regions and LV traits, and we then conducted single CpG analyses within significant DMRs. We identified associations between DMRs and ejection fraction (
Identifiants
pubmed: 36292585
pii: genes13101700
doi: 10.3390/genes13101700
pmc: PMC9601679
pii:
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : F31 DK128990
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800015I
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31DK128990
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800012I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800011I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800010I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800014I
Pays : United States
Organisme : NIMHD NIH HHS
ID : HHSN268201800013I
Pays : United States
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