Integrated Bioinformatics Analysis Reveals Novel miRNA as Biomarkers Associated with Preeclampsia.
bioinformatics
biomarkers
epigenetic
microRNA
preeclampsia
therapeutic targets
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
02 10 2022
02 10 2022
Historique:
received:
28
07
2022
revised:
27
09
2022
accepted:
27
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Preeclampsia is a leading cause of perinatal maternal-foetal mortality and morbidity. This study aims to identify the key microRNAs (miRNA) in preeclampsia and uncover their potential functions. We downloaded the miRNA expression profile of GSE119799 for plasma and GSE177049 for the placenta. Each dataset consisted of five patients (PE) and five controls (N). From a technical point of view, we analysed the counts per million (CPM) for both datasets, highlighting 358 miRNAs in common, 78 unique for plasma and 298 unique for placenta. At the same time, we performed an expression differential analysis (|logFC| ≥ 1|and FDR ≤ 0.05) to evaluate the biological impact of the miRNAs. This approach allowed us to highlight 321 miRNAs in common between plasma and placenta, within which four were upregulated in plasma. Furthermore, the same analysis revealed five miRNAs expressed exclusively in plasma; these were also upregulated. In conclusion, the in-depth bioinformatics analysis conducted during our study will allow us, on the one hand, to verify the targets of each of the nine identified miRNAs; on the other hand, to use them both as new non-invasive biomarkers and as therapeutic targets for the development of
Identifiants
pubmed: 36292666
pii: genes13101781
doi: 10.3390/genes13101781
pmc: PMC9601722
pii:
doi:
Substances chimiques
MicroRNAs
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Biomed Sci. 2021 Feb 20;28(1):14
pubmed: 33610185
J Clin Endocrinol Metab. 2000 May;85(5):1828-33
pubmed: 10843160
Cells. 2021 Apr 27;10(5):
pubmed: 33925602
Mol Med Rep. 2017 Nov;16(5):6650-6673
pubmed: 28901463
Genes (Basel). 2019 Dec 23;11(1):
pubmed: 31877923
Sci Rep. 2020 Nov 18;10(1):20065
pubmed: 33208781
J Clin Med. 2019 May 09;8(5):
pubmed: 31075910
Bioengineered. 2021 Dec;12(2):9140-9149
pubmed: 34696680
Endocrinology. 2018 May 1;159(5):2022-2033
pubmed: 29546425
Am Fam Physician. 2004 Dec 15;70(12):2317-24
pubmed: 15617295
J Cell Physiol. 2014 Nov;229(11):1630-8
pubmed: 24610393
Cancer Biol Ther. 2016 Nov;17(11):1149-1157
pubmed: 27686621
Auris Nasus Larynx. 2019 Feb;46(1):106-113
pubmed: 29843929
Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3142-3152
pubmed: 28844950
Int J Mol Sci. 2019 Feb 14;20(4):
pubmed: 30769772
Front Biosci (Landmark Ed). 2014 Jan 01;19(5):734-46
pubmed: 24389217
Genome Res. 2009 Jan;19(1):92-105
pubmed: 18955434
Mol Cell. 2007 Jul 6;27(1):91-105
pubmed: 17612493
FASEB J. 2017 Jul;31(7):2760-2770
pubmed: 28289056
Front Microbiol. 2020 Jun 03;11:1197
pubmed: 32582115
Front Immunol. 2019 Oct 25;10:2543
pubmed: 31708933
Biomed Pharmacother. 2019 Jul;115:108953
pubmed: 31075732
Sci Rep. 2019 Dec 2;9(1):18091
pubmed: 31792344
J Transl Med. 2020 Jan 22;18(1):32
pubmed: 31969163
Cells. 2022 Sep 07;11(18):
pubmed: 36139370
Toxicol Res (Camb). 2018 Feb 8;7(3):415-422
pubmed: 30090591
Int J Mol Sci. 2022 Mar 22;23(7):
pubmed: 35408809
Placenta. 2016 Jul;43:81-5
pubmed: 27324104
Mol Ther Nucleic Acids. 2020 Sep 4;21:278-289
pubmed: 32615527
J Am Soc Nephrol. 2021 Jun 1;32(6):1339-1354
pubmed: 33727367
Adv Nutr. 2017 Nov 15;8(6):868-888
pubmed: 29141971
Front Cardiovasc Med. 2020 Oct 23;7:586871
pubmed: 33195475
Nucleic Acids Res. 2020 Jul 2;48(W1):W244-W251
pubmed: 32484539
Pregnancy Hypertens. 2017 Oct;10:149-154
pubmed: 29153669
Front Bioeng Biotechnol. 2021 Dec 24;9:782845
pubmed: 35004644
Am J Pathol. 2001 Nov;159(5):1827-38
pubmed: 11696443
Antibiotics (Basel). 2020 Jun 07;9(6):
pubmed: 32517339
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Eur J Endocrinol. 2008 Jan;158(1):101-5
pubmed: 18166823
Nucleic Acids Res. 2020 Jan 8;48(D1):D127-D131
pubmed: 31504780
Front Genet. 2021 Jul 23;12:712150
pubmed: 34367263
Nat Struct Mol Biol. 2011 Sep 11;18(10):1139-46
pubmed: 21909094
In Vivo. 2020 Sep-Oct;34(5):2317-2324
pubmed: 32871756
Rev Clin Exp Hematol. 2001 Dec;5(4):335-68; quiz following 431
pubmed: 11844133
Mol Med Rep. 2016 Jul;14(1):22-32
pubmed: 27176897
Microrna. 2019;8(1):28-35
pubmed: 30101723
Front Cell Dev Biol. 2021 Mar 11;9:646326
pubmed: 33777951
Cell. 2009 Jan 23;136(2):215-33
pubmed: 19167326
Endocrinology. 2019 Feb 1;160(2):249-275
pubmed: 30358826
Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E836-43
pubmed: 23443922
Cell. 2005 Jan 14;120(1):15-20
pubmed: 15652477
Int J Gynaecol Obstet. 2004 Mar;84(3):214-9
pubmed: 15001368
Semin Thromb Hemost. 2001 Dec;27(6):657-66
pubmed: 11740689
Nature. 2004 Sep 16;431(7006):350-5
pubmed: 15372042
Glob Health Sci Pract. 2015 Dec 17;3(4):525-7
pubmed: 26681699
Science. 2019 Dec 20;366(6472):
pubmed: 31806698
Cardiovasc J Afr. 2016 Mar-Apr;27(2):71-8
pubmed: 27213853
Clin Epigenetics. 2018 Mar 22;10:39
pubmed: 29588807
Semin Nephrol. 2011 Jan;31(1):33-46
pubmed: 21266263
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Acta Obstet Gynecol Scand. 1985;64(3):227-9
pubmed: 4013686
Cancer Drug Resist. 2021 Oct 26;4(4):934-945
pubmed: 35582382
Cell. 2006 Sep 22;126(6):1203-17
pubmed: 16990141
Kaohsiung J Med Sci. 2020 Feb;36(2):114-121
pubmed: 31688986
Int J Med Sci. 2020 Feb 24;17(5):664-677
pubmed: 32210717
Genome Biol. 2019 Jan 22;20(1):18
pubmed: 30670076
Exp Mol Med. 2018 Mar 30;50(3):e465
pubmed: 29869625
Eur Rev Med Pharmacol Sci. 2020 May;24(10):5223-5230
pubmed: 32495855
Elife. 2015 Aug 12;4:
pubmed: 26267216