The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway.
Alzheimer disease
GSK3 phosphorylation
Wnt signaling
flavonoid
quercetin glycoside
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Oct 2022
11 Oct 2022
Historique:
received:
09
08
2022
revised:
09
09
2022
accepted:
10
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The Wnt/β-catenin signaling pathway dictates cell proliferation and differentiation during embryonic development and tissue homeostasis. Its deregulation is associated with many pathological conditions, including neurodegenerative disease, frequently downregulated. The lack of efficient treatment for these diseases, including Alzheimer's disease (AD), makes Wnt signaling an attractive target for therapies. Interestingly, novel Wnt signaling activating compounds are less frequently described than inhibitors, turning the quest for novel positive modulators even more appealing. In that sense, natural compounds are an outstanding source of potential drug leads. Here, we combine different experimental models, cell-based approaches, neuronal culture assays, and rodent behavior tests with
Identifiants
pubmed: 36292931
pii: ijms232012078
doi: 10.3390/ijms232012078
pmc: PMC9602613
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
beta Catenin
0
Glycogen Synthase Kinase 3
EC 2.7.11.26
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Quercetin
9IKM0I5T1E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/200.936/2022
Organisme : National Council for Scientific and Technological Development
ID : 465346/2014-6
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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