Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors.
apoptosis
photoreceptor degeneration
sequencing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Oct 2022
12 Oct 2022
Historique:
received:
29
08
2022
revised:
28
09
2022
accepted:
08
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood. The aim of this study was to systematically map the transcriptional changes that occur in the degenerating mouse retina at the single cell level. To this end, we employed single-cell RNA-sequencing (scRNA-seq) and retinal degeneration-1 (
Identifiants
pubmed: 36293024
pii: ijms232012170
doi: 10.3390/ijms232012170
pmc: PMC9603353
pii:
doi:
Substances chimiques
Mitogen-Activated Protein Kinases
EC 2.7.11.24
RNA
63231-63-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : German Research Council
ID : PA1751/10-1
Organisme : National Natural Science Foundation of China
ID : 81960180
Organisme : Yunnan Applied Basic Research Projects
ID : 2019FB093
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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