Biological Activity of Different Forms of Oxidized Parathyroid Hormone.

Humans Parathyroid Hormone / metabolism Prospective Studies Oxidation-Reduction Renal Insufficiency, Chronic Methionine / metabolism
chronic kidney disease-mineral bone disorder (CKD-MBD) oxidative stress parathyroid hormone

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
13 Oct 2022
Historique:
received: 18 08 2022
revised: 10 10 2022
accepted: 11 10 2022
entrez: 27 10 2022
pubmed: 28 10 2022
medline: 29 10 2022
Statut: epublish

Résumé

Preclinical studies have shown that parathyroid hormone (PTH) loses its biological effects through oxidation. PTH can be oxidized at methionines 8 and 18. Three possible variations of oxidized PTH (oxPTH) exist: Met8(ox)PTH, Met18(ox)PTH, and Met8, Met18(di-ox)PTH. A recent study showed that Met18(ox)PTH retained biological activity and was able to upregulate

Identifiants

DOI: 10.3390/ijms232012228 PMID: 36293083 PMC: PMC9603367
pubmed: 36293083
pii: ijms232012228
doi: 10.3390/ijms232012228
pmc: PMC9603367
pii:
doi:

Substances chimiques

Parathyroid Hormone 0
Methionine AE28F7PNPL

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Ahmed A Hasan (AA)

Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.
Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
ORCID: 0000-0002-0382-4916

Carl-Friedrich Hocher (CF)

Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.
Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Klinik für Innere Medizin, Bundeswehrkrankenhaus Berlin, 10115 Berlin, Germany.

Burkhard Kleuser (B)

Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.
ORCID: 0000-0002-1888-9595

Bernhard K Krämer (BK)

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
European Center for Angioscience, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.

Berthold Hocher (B)

Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.
Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410081, China.
Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China.
Institute of Medical Diagnostics, IMD Berlin, 12247 Berlin, Germany.
ORCID: 0000-0001-8143-0579

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biological Activity of Different Forms of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormone parathyroïdienne › Biological Activity of Different Forms of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Biological Activity of Different Forms of...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Biological Activity of Different Forms of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Biological Activity of Different Forms of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Biological Activity of Different Forms of...