Chalcone-Acridine Hybrid Suppresses Melanoma Cell Progression via G2/M Cell Cycle Arrest, DNA Damage, Apoptosis, and Modulation of MAP Kinases Activity.
Humans
Chalcone
/ pharmacology
Cyclin B1
/ metabolism
Chalcones
/ pharmacology
Phosphorylation
bcl-2-Associated X Protein
/ metabolism
Caspase 3
/ metabolism
Acridines
/ pharmacology
Cytochromes c
/ metabolism
Cell Line, Tumor
G2 Phase Cell Cycle Checkpoints
Apoptosis
DNA Damage
Cell Cycle Checkpoints
Cell Cycle Proteins
/ metabolism
Melanoma
/ drug therapy
DNA damage
MAP kinases
apoptosis
cell cycle arrest
chalcone-acridine hybrid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Oct 2022
14 Oct 2022
Historique:
received:
07
09
2022
revised:
10
10
2022
accepted:
11
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
This study was focused on investigating the antiproliferative effects of chalcone hybrids in melanoma cancer cells. Among seven chalcone hybrids, the chalcone-acridine hybrid
Identifiants
pubmed: 36293123
pii: ijms232012266
doi: 10.3390/ijms232012266
pmc: PMC9603750
pii:
doi:
Substances chimiques
Chalcone
5S5A2Q39HX
Cyclin B1
0
Chalcones
0
bcl-2-Associated X Protein
0
Caspase 3
EC 3.4.22.-
Acridines
0
Cytochromes c
9007-43-6
Cell Cycle Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grant Agency of the Ministry of the Education, Science, Research and Sport of the Slovak Republic
ID : VEGA 1/0653/19
Organisme : Grant Agency of the Ministry of the Education, Science, Research and Sport of the Slovak Republic
ID : VEGA 1/0539/21
Organisme : Slovak Research and Development Agency
ID : APVV 16-0446
Organisme : Open scientific community for modern interdisciplinary research in medicine (OPENMED),supported by the Operational Programme Integrated Infrastructure, funded by the ERDF
ID : ITMS2014+: 313011V455
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