The Binding of CSL Proteins to Either Co-Activators or Co-Repressors Protects from Proteasomal Degradation Induced by MAPK-Dependent Phosphorylation.
CSL
MAPK
Notch signalling dynamics
activator complex
degron
proteasomal degradation
protein stability
repressor complex
suppressor of hairless
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Oct 2022
15 Oct 2022
Historique:
received:
28
09
2022
revised:
12
10
2022
accepted:
13
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The primary role of Notch is to specify cellular identities, whereby the cells respond to amazingly small changes in Notch signalling activity. Hence, dosage of Notch components is crucial to regulation. Central to Notch signal transduction are CSL proteins: together with respective cofactors, they mediate the activation or the silencing of Notch target genes. CSL proteins are extremely similar amongst species regarding sequence and structure. We noticed that the fly homologue suppressor of hairless (Su(H)) is stabilised in transcription complexes. Using specific transgenic fly lines and HeLa RBPJ
Identifiants
pubmed: 36293193
pii: ijms232012336
doi: 10.3390/ijms232012336
pmc: PMC9604145
pii:
doi:
Substances chimiques
Drosophila Proteins
0
Co-Repressor Proteins
0
Receptors, Notch
0
Repressor Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : NA 427/5-1
Organisme : Deutsche Forschungsgemeinschaft
ID : MA 1328/11-1
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