Bis(Benzofuran-1,3-
antiviral
benzimidazole
benzofuran
bis-conjugated compound
imidazolidinone
yellow fever virus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Oct 2022
21 Oct 2022
Historique:
received:
23
08
2022
revised:
14
10
2022
accepted:
19
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The yellow fever virus (YFV) is an emerging RNA virus and has caused large outbreaks in Africa and Central and South America. The virus is often transmitted through infected mosquitoes and spreads from area to area because of international travel. Being an acute viral hemorrhagic disease, yellow fever can be prevented by an effective, safe, and reliable vaccine, but not be eliminated. Currently, there is no antiviral drug available for its cure. Thus, two series of novel bis(benzofuran−1,3-imidazolidin-4-one)s and bis(benzofuran−1,3-benzimidazole)s were designed and synthesized for the development of anti-YFV lead candidates. Among 23 new bis-conjugated compounds, 4 of them inhibited YFV strain 17D (Stamaril) on Huh-7 cells in the cytopathic effect reduction assays. These conjugates exhibited the most compelling efficacy and selectivity with an EC50 of <3.54 μM and SI of >15.3. The results are valuable for the development of novel antiviral drug leads against emerging diseases.
Identifiants
pubmed: 36293531
pii: ijms232012675
doi: 10.3390/ijms232012675
pmc: PMC9604066
pii:
doi:
Substances chimiques
Synthetic Drugs
0
Yellow Fever Vaccine
0
Benzofurans
0
Antiviral Agents
0
Benzimidazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Taiwan
ID : 111QR001I5 and 110QR001I5
Organisme : National Science and Technology Council (NSTC), Taiwan
ID : 111-2634-F-007-023 and 111-2113-M-007-027
Organisme : the European Commission within the 7th Framework Programme
ID : 260644
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