The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review.
BDNF
immunity
sleep medicine
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
12 Oct 2022
12 Oct 2022
Historique:
received:
20
09
2022
revised:
05
10
2022
accepted:
10
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Brain-derived neurotrophic factor (BDNF) is a neurotrophin regulating synaptic plasticity, neuronal excitability, and nociception. It seems to be one of the key molecules in interactions between the central nervous system and immune-related diseases, i.e., diseases with an inflammatory background of unknown etiology, such as inflammatory bowel diseases or rheumatoid arthritis. Studies show that BDNF levels might change in the tissues and serum of patients during the course of these conditions, e.g., affecting cell survival and modulating pain severity and signaling pathways involving different neurotransmitters. Immune-related conditions often feature psychiatric comorbidities, such as sleep disorders (e.g., insomnia) and symptoms of depression/anxiety; BDNF may be related as well to them as it seems to exert an influence on sleep structure; studies also show that patients with psychiatric disorders have decreased BDNF levels, which increase after treatment. BDNF also has a vital role in nociception, particularly in chronic pain, hyperalgesia, and allodynia, participating in the formation of central hypersensitization. In this review, we summarize the current knowledge on BDNF's function in immune-related diseases, sleep, and pain. We also discuss how BDNF is affected by treatment and what consequences these changes might have beyond the nervous system.
Identifiants
pubmed: 36294343
pii: jcm11206023
doi: 10.3390/jcm11206023
pmc: PMC9604720
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Science Centre, Poland
ID : 2018/31/N/NZ5/03715
Organisme : Ministry of Education and Science, Poland
ID : SKN/SP/496681/2021
Références
Neurogastroenterol Motil. 2021 Jun;33(6):e13978
pubmed: 32869433
Acta Biochim Biophys Sin (Shanghai). 2020 Jun 20;52(6):675-682
pubmed: 32445466
Neurol Neurochir Pol. 2017 Jan - Feb;51(1):24-32
pubmed: 28341039
Neuroscience. 2013 Jun 3;239:149-56
pubmed: 23402850
Psych J. 2021 Apr;10(2):283-294
pubmed: 33378796
Int J Mol Sci. 2020 Oct 21;21(20):
pubmed: 33096634
J Sleep Res. 2004 Dec;13(4):385-93
pubmed: 15560773
Int J Mol Sci. 2018 Mar 03;19(3):
pubmed: 29510522
Indian J Pharmacol. 2017 May-Jun;49(3):236-242
pubmed: 29033483
Clin Gastroenterol Hepatol. 2013 Aug;11(8):965-71
pubmed: 23376797
Rev Pain. 2008 Sep;2(1):2-7
pubmed: 26525182
Sleep. 2012 Mar 01;35(3):309-10
pubmed: 22379234
Gastroenterol Clin North Am. 2017 Mar;46(1):77-89
pubmed: 28164854
Mov Disord. 2010;25 Suppl 1:S98-103
pubmed: 20187254
Mol Pain. 2014 Jul 08;10:46
pubmed: 25005881
Neurochem Res. 2010 May;35(5):830-4
pubmed: 20119637
Int J Immunopathol Pharmacol. 2015 Dec;28(4):443-51
pubmed: 26526203
J Neurosci. 2001 Jun 15;21(12):4249-58
pubmed: 11404410
Nat Rev Drug Discov. 2011 Mar;10(3):209-19
pubmed: 21358740
Neuroreport. 2001 Aug 28;12(12):2673-7
pubmed: 11522946
J Pain. 2009 Sep;10(9):895-926
pubmed: 19712899
Front Neurol. 2019 Aug 13;10:849
pubmed: 31456736
Medicine (Baltimore). 2020 Nov 25;99(48):e23430
pubmed: 33235125
Cell Death Differ. 2011 Dec;18(12):1889-903
pubmed: 21660047
Neural Regen Res. 2015 May;10(5):721-5
pubmed: 26109945
Evid Based Complement Alternat Med. 2014;2014:203173
pubmed: 25120574
Neurosci Lett. 2009 Apr 17;454(1):16-21
pubmed: 19429046
Neuron. 1997 Feb;18(2):257-67
pubmed: 9052796
Neuron. 1999 Jun;23(2):353-64
pubmed: 10399940
Physiol Res. 2017 Dec 20;66(6):1009-1020
pubmed: 28937245
Sci Rep. 2013 Nov 11;3:3185
pubmed: 24212565
Front Behav Neurosci. 2015 Sep 15;9:253
pubmed: 26441580
Neurochem Res. 2010 Jul;35(7):1098-104
pubmed: 20361354
J Neurosci. 2000 Jun 1;20(11):4165-76
pubmed: 10818152
Pharmacol Rep. 2022 Feb;74(1):84-95
pubmed: 34569017
Neurochem Res. 2020 Feb;45(2):221-231
pubmed: 31782101
Mult Scler Relat Disord. 2022 Sep;65:103984
pubmed: 35749959
J Pharmacol Exp Ther. 2006 Sep;318(3):933-8
pubmed: 16644899
Mol Cell Neurosci. 2000 May;15(5):446-55
pubmed: 10833301
Neurochem Res. 2018 Dec;43(12):2353-2361
pubmed: 30324331
Nat Neurosci. 2007 Sep;10(9):1089-93
pubmed: 17726474
Transl Psychiatry. 2017 May 16;7(5):e1128
pubmed: 28509900
Neurogenetics. 2016 Oct;17(4):201-210
pubmed: 27318935
Brain Res Bull. 1995;38(6):539-43
pubmed: 8590075
Biol Psychiatry. 2007 Sep 1;62(5):521-9
pubmed: 17336942
Brain. 2018 Apr 1;141(4):1028-1039
pubmed: 29394316
Transl Issues Psychol Sci. 2015 Mar 1;1(1):57-66
pubmed: 25914895
PLoS One. 2017 Feb 27;12(2):e0172270
pubmed: 28241064
Prog Neurobiol. 2008 Jul;85(3):297-317
pubmed: 18514997
BMC Musculoskelet Disord. 2022 May 2;23(1):411
pubmed: 35501732
Sleep. 2018 Feb 1;41(2):
pubmed: 29462410
Neuroscience. 2011 Apr 28;180:322-33
pubmed: 21335064
Front Cell Neurosci. 2019 Aug 07;13:363
pubmed: 31440144
Neuropsychiatr Dis Treat. 2016 Jul 25;12:1843-8
pubmed: 27524902
J Immunol. 2013 May 1;190(9):4795-804
pubmed: 23554310
Adv Exp Med Biol. 2014;817:195-219
pubmed: 24997035
Molecules. 2021 Apr 19;26(8):
pubmed: 33921721
J Investig Dermatol Symp Proc. 2005 Dec;10(3):282
pubmed: 16402482
J Biol Rhythms. 2017 Feb;32(1):75-82
pubmed: 28326910
J Appl Microbiol. 2012 Aug;113(2):411-7
pubmed: 22612585
J Neurosci Res. 2017 Jun;95(6):1282-1294
pubmed: 27448322
Dev Neurobiol. 2012 Jun;72(6):943-52
pubmed: 22252978
Int J Mol Sci. 2021 Nov 21;22(22):
pubmed: 34830418
Neuroimmunomodulation. 2021;28(3):150-157
pubmed: 34182566
Neuropharmacology. 2016 Mar;102:72-9
pubmed: 26519901
Int J Yoga. 2017 Jan-Apr;10(1):9-15
pubmed: 28149062
Gastroenterol Hepatol (N Y). 2011 Sep;7(9):592-601
pubmed: 22298998
J Cell Biochem. 2013 Jan;114(1):144-51
pubmed: 22886995
Int J Inflam. 2011;2011:650685
pubmed: 21755028
Arthritis Res Ther. 2009;11(3):R82
pubmed: 19490633
PLoS One. 2014 May 06;9(5):e96410
pubmed: 24801982
Dig Dis Sci. 2022 Jul;67(7):3096-3107
pubmed: 34331174
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8191-5
pubmed: 9223337
Restor Neurol Neurosci. 2004;22(2):121-30
pubmed: 15272146
Pediatr Gastroenterol Hepatol Nutr. 2019 Nov;22(6):527-535
pubmed: 31777718
Neuron. 2019 Jul 17;103(2):250-265.e8
pubmed: 31122677
Can J Gastroenterol Hepatol. 2018 Sep 9;2018:2047242
pubmed: 30271765
J Biol Chem. 2007 Apr 27;282(17):12619-28
pubmed: 17337442
Inflamm Bowel Dis. 2009 May;15(5):778-88
pubmed: 19130619
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3742-3744
pubmed: 29592951
Cells Tissues Organs. 2008;188(3):299-309
pubmed: 18349525
Acta Neuropathol. 2012 Feb;123(2):247-58
pubmed: 22009304
Clin Exp Immunol. 2010 Apr;160(1):1-9
pubmed: 20415844
Clin Rheumatol. 2018 Jul;37(7):1825-1834
pubmed: 29654486
Front Pharmacol. 2018 Oct 10;9:1143
pubmed: 30364099
J Physiol. 2017 Jul 1;595(13):4141-4150
pubmed: 28369946
Front Behav Neurosci. 2017 May 31;11:101
pubmed: 28620285
Aliment Pharmacol Ther. 2009 Apr 15;29(8):834-42
pubmed: 19226291
Sci Rep. 2017 Jun 14;7(1):3545
pubmed: 28615695
Sci Rep. 2020 Sep 11;10(1):14984
pubmed: 32917932
Joint Bone Spine. 2022 Jul;89(4):105397
pubmed: 35500798
Front Psychiatry. 2018 May 29;9:223
pubmed: 29896129
Neurogastroenterol Motil. 2018 Oct;30(10):e13446
pubmed: 30259610
Am J Physiol Gastrointest Liver Physiol. 2020 Dec 1;319(6):G761-G768
pubmed: 32967429
Brain Sci. 2020 Mar 25;10(4):
pubmed: 32218234
J Neurosci. 2011 Jun 29;31(26):9735-45
pubmed: 21715638
J Neurosci. 1999 Nov 15;19(22):9928-38
pubmed: 10559401
Nat Neurosci. 2000 Apr;3(4):323-9
pubmed: 10725920
Ann Palliat Med. 2020 Jul;9(4):1361-1365
pubmed: 32527133
Sleep. 2018 Sep 1;41(9):
pubmed: 29955877
BMC Genomics. 2021 Mar 23;22(1):207
pubmed: 33757426
Biol Psychiatry. 2014 Feb 15;75(4):300-6
pubmed: 24199668
Stress. 2021 Jul;24(4):442-449
pubmed: 33236949
PLoS One. 2020 Jan 17;15(1):e0227834
pubmed: 31951637
PLoS One. 2016 Jun 22;11(6):e0156666
pubmed: 27332879
Pancreas. 2002 Jul;25(1):31-8
pubmed: 12131768
J Neuroimmunol. 2005 Mar;160(1-2):204-9
pubmed: 15710474
J Food Biochem. 2022 Sep 27;:e14436
pubmed: 36166506
Neuroscientist. 2002 Dec;8(6):524-31
pubmed: 12467374
Sleep. 2022 Feb 14;45(2):
pubmed: 34537852
J Neurophysiol. 2005 Sep;94(3):1798-804
pubmed: 15901762
Clin Rheumatol. 2008 Oct;27(10):1289-97
pubmed: 18484150
J Neurosci. 2018 Aug 8;38(32):7088-7099
pubmed: 29976621
Neurobiol Dis. 2010 Sep;39(3):327-33
pubmed: 20451611
Ann Med. 2016;48(1-2):42-51
pubmed: 26758201
PLoS Biol. 2021 Jul 22;19(7):e3001337
pubmed: 34292944
Psychiatr Pol. 2016;50(4):747-760
pubmed: 27847926
Acta Derm Venereol. 2010;90(1):39-45
pubmed: 20107724
Nat Rev Neurosci. 2012 Feb 15;13(3):169-82
pubmed: 22334212
Neurosci Res. 2009 Sep;65(1):11-22
pubmed: 19523993
Brain Res Mol Brain Res. 1998 Mar 30;55(1):20-7
pubmed: 9645956
Front Psychiatry. 2019 Mar 20;10:131
pubmed: 30949074
J Mol Cell Cardiol. 2014 Mar;68:89-97
pubmed: 24462831
J Neurosci. 2008 Apr 9;28(15):4088-95
pubmed: 18400908
Int Rev Psychiatry. 2016 Jun;28(3):273-8
pubmed: 27174729
BMC Rheumatol. 2018 Apr 05;2:11
pubmed: 30886962
Am J Physiol Regul Integr Comp Physiol. 2015 Feb 1;308(3):R199-207
pubmed: 25502751
Biol Psychiatry. 2019 Jan 1;85(1):35-48
pubmed: 30122288
Kidney Blood Press Res. 2019;44(4):435-448
pubmed: 31307039
Gastroenterology. 2006 Mar;130(3):771-80
pubmed: 16530518
J Clin Med. 2021 Dec 23;11(1):
pubmed: 35011807
Clin Pract Epidemiol Ment Health. 2017 Nov 21;13:213-219
pubmed: 29299044
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3876-81
pubmed: 20133677
J Neuroimmunol. 2020 Dec 15;349:577406
pubmed: 33002723
Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):
pubmed: 34140411
J Exp Med. 1999 Mar 1;189(5):865-70
pubmed: 10049950
Mol Neurobiol. 2019 May;56(5):3295-3312
pubmed: 30117106
Cell Mol Neurobiol. 2016 Aug;36(6):915-925
pubmed: 26440805
Mol Med Rep. 2013 Oct;8(4):1011-6
pubmed: 23942837
Arthritis Care Res (Hoboken). 2013 Aug;65(8):1291-8
pubmed: 23335582
Am J Physiol. 1999 May;276(5):R1334-8
pubmed: 10233024
Cell Mol Neurobiol. 2018 Apr;38(3):579-593
pubmed: 28623429
Sci Rep. 2021 Jan 14;11(1):1440
pubmed: 33446900
Neurol Neurochir Pol. 2017 May - Jun;51(3):221-226
pubmed: 28392137
Front Neurol. 2021 Mar 16;12:645220
pubmed: 33815257
J Anat. 2003 Jul;203(1):1-19
pubmed: 12892403
J Neurosci Res. 2000 Aug 1;61(3):295-301
pubmed: 10900076
Life Sci. 2007 May 30;80(24-25):2206-9
pubmed: 17363003
Lupus. 2018 Aug;27(9):1524-1531
pubmed: 29804502
Curr Neurovasc Res. 2015;12(2):135-46
pubmed: 25760219
Learn Mem. 2004 Mar-Apr;11(2):172-8
pubmed: 15054132
Cytotherapy. 2019 Jun;21(6):671-682
pubmed: 31076196
J Appl Biobehav Res. 2018 Jun;23(2):
pubmed: 30479469
Neural Plast. 2016;2016:6860573
pubmed: 27437149
Neurosci Lett. 2013 Nov 27;556:37-41
pubmed: 24141084
Growth Factors. 2004 Sep;22(3):123-31
pubmed: 15518235
Int J Yoga Therap. 2015;25(1):101-12
pubmed: 26667293
Ann Rheum Dis. 2005 Nov;64(11):1542-9
pubmed: 15817657
Sleep. 2015 Apr 01;38(4):581-6
pubmed: 25669189
Dig Liver Dis. 2019 Jan;51(1):38-42
pubmed: 30309751
Curr Opin Immunol. 1995 Dec;7(6):793-8
pubmed: 8679122
Brain Behav Immun. 2018 Oct;73:274-281
pubmed: 29787856
Rheumatology (Oxford). 2014 Dec;53(12):2182-90
pubmed: 24942492
J Sleep Res. 2014 Apr;23(2):124-32
pubmed: 24635564
Mol Psychiatry. 2014 Feb;19(2):151-2
pubmed: 23399916