A Perspective: Challenges in Dementia Research.

Alzheimer’s disease big data biomarkers dementia imaging neurophysiology

Journal

Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208

Informations de publication

Date de publication:
28 Sep 2022
Historique:
received: 31 08 2022
revised: 21 09 2022
accepted: 27 09 2022
entrez: 27 10 2022
pubmed: 28 10 2022
medline: 29 10 2022
Statut: epublish

Résumé

Although dementia is a common and devastating disease that has been studied intensely for more than 100 years, no effective disease modifying treatment has been found. At this impasse, new approaches are important. The purpose of this paper is to provide, in the context of current research, one clinician's perspective regarding important challenges in the field in the form of specific challenges. These challenges not only illustrate the scope of the problems inherent in finding treatments for dementia, but can also be specific targets to foster discussion, criticism and new research. One common theme is the need to transform research activities from small projects in individual laboratories/clinics to larger multinational projects, in which each clinician and researcher works as an integral part. This transformation will require collaboration between researchers, large corporations, regulatory/governmental authorities and the general population, as well as significant financial investments. However, the costs of transforming the approach are small in comparison with the cost of dementia.

Identifiants

pubmed: 36295529
pii: medicina58101368
doi: 10.3390/medicina58101368
pmc: PMC9609997
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

PLoS Comput Biol. 2022 Jul 15;18(7):e1010212
pubmed: 35839259
J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):659-663
pubmed: 34687299
Neurologist. 2021 Mar 4;26(2):52-61
pubmed: 33646990
Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12218
pubmed: 35005203
Cochrane Database Syst Rev. 2022 Jun 16;6:CD012558
pubmed: 35709018
Acta Neuropathol. 2022 Jul;144(1):27-44
pubmed: 35697880
Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2347-54
pubmed: 16321805
Comput Biol Med. 2022 Aug;147:105695
pubmed: 35785665
Psychol Med. 1997 Jul;27(4):919-30
pubmed: 9234469
J Alzheimers Dis. 2020;74(1):213-225
pubmed: 31985466
Int J Mol Sci. 2019 Sep 26;20(19):
pubmed: 31561483
Int J Mol Sci. 2022 Jul 18;23(14):
pubmed: 35887259
Medicina (Kaunas). 2022 Jul 19;58(7):
pubmed: 35888671
Alzheimer Dis Assoc Disord. 1998 Sep;12(3):182-9
pubmed: 9772021
J Neural Eng. 2019 Sep 17;16(5):056030
pubmed: 31112938
Elife. 2022 Aug 08;11:
pubmed: 35938915
JAMA. 2019 Oct 22;322(16):1589-1599
pubmed: 31638686
Adv Drug Deliv Rev. 2022 Sep;188:114421
pubmed: 35809868
J Clin Sleep Med. 2018 Oct 15;14(10):1765-1772
pubmed: 30353817
Curr Drug Targets. 2022;23(3):266-285
pubmed: 34370634
J Neurol Neurosurg Psychiatry. 2022 Mar;93(3):246-253
pubmed: 35086942
Neurobiol Aging. 2020 Jan;85:58-73
pubmed: 31739167
Brain. 2018 Apr 1;141(4):1186-1200
pubmed: 29462334
Ageing Res Rev. 2022 Aug;79:101654
pubmed: 35636691
Curr Opin Neurobiol. 2022 Feb;72:120-130
pubmed: 34818608
Nat Commun. 2022 Mar 28;13(1):1643
pubmed: 35347127
Clin Anat. 1995;8(6):429-31
pubmed: 8713166
Neurobiol Aging. 1999 Mar-Apr;20(2):201-11
pubmed: 10537029
Int Psychogeriatr. 1997;9 Suppl 1:191-222; discussion 247-52
pubmed: 9447442
Neuropsychology. 2022 Oct;36(7):651-663
pubmed: 35951411
Alzheimers Res Ther. 2022 May 23;14(1):71
pubmed: 35606871
Am J Ind Med. 2001 Apr;39(4):361-8
pubmed: 11323785
Clin Nucl Med. 2022 Sep 1;47(9):763-773
pubmed: 35543643
Ageing Res Rev. 2021 Dec;72:101491
pubmed: 34688925
Comput Methods Programs Biomed. 2017 May;143:89-95
pubmed: 28391822
Int J Mol Sci. 2022 May 12;23(10):
pubmed: 35628216
BMC Med. 2022 Aug 15;20(1):252
pubmed: 35965319
Neuroimage Clin. 2022;35:103040
pubmed: 35653914
EClinicalMedicine. 2022 Jul 22;51:101580
pubmed: 35898316
Arch Clin Neuropsychol. 2007 Mar;22(3):355-65
pubmed: 17320344
Aging Clin Exp Res. 2016 Jun;28(3):491-6
pubmed: 26341489
J Clin Med. 2020 Oct 27;9(11):
pubmed: 33121040
Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):351-358
pubmed: 30376508
Cochrane Database Syst Rev. 2021 Feb 10;2:CD010945
pubmed: 33566374
J Neural Transm Suppl. 1996;47:143-53
pubmed: 8841962
Emerg Top Life Sci. 2021 Dec 21;5(6):765-777
pubmed: 34881778
BMC Neurol. 2020 Mar 26;20(1):110
pubmed: 32216773
Neurology. 2005 Jul 12;65(1):102-6
pubmed: 16009893
Aging (Albany NY). 2018 Oct 31;10(10):3017-3041
pubmed: 30383539
Expert Opin Drug Discov. 2017 Feb;12(2):187-200
pubmed: 27960560
Phys Chem Chem Phys. 2022 Apr 20;24(16):9051-9081
pubmed: 35389399
Neuronal Signal. 2022 Apr 08;6(1):NS20210054
pubmed: 35449591
Alzheimers Dement. 2021 Jun;17(6):1005-1016
pubmed: 33480178
Bioengineering (Basel). 2022 Aug 05;9(8):
pubmed: 36004895
Front Aging Neurosci. 2022 Jul 19;14:903269
pubmed: 35928996
Int J Mol Sci. 2018 Oct 29;19(11):
pubmed: 30380679
J Geriatr Psychiatry Neurol. 1993 Apr-Jun;6(2):84-96
pubmed: 8512635
Int J Mol Sci. 2022 Aug 02;23(15):
pubmed: 35955728
Neuroscience. 2020 Jan 1;424:45-57
pubmed: 31682825
Int J Mol Sci. 2022 Jun 29;23(13):
pubmed: 35806226
Biochemistry. 2022 Jul 5;61(13):1243-1259
pubmed: 35731895
Neuropsychol Rev. 1998 Mar;8(1):11-23
pubmed: 9585920
Nat Rev Neurol. 2021 Sep;17(9):545-563
pubmed: 34285392
Arch Phys Med Rehabil. 1975 Oct;56(10):425-37
pubmed: 1190996
Molecules. 2022 Apr 12;27(8):
pubmed: 35458686
J Neural Transm Suppl. 1994;44:111-32
pubmed: 7897385
Chem Biol Interact. 2022 Sep 1;364:110065
pubmed: 35872043
Brain Pathol. 2012 Sep;22(5):636-53
pubmed: 22188425
JAMA Neurol. 2022 Aug 1;79(8):797-807
pubmed: 35789365
Biomolecules. 2021 Jul 03;11(7):
pubmed: 34356604
Alzheimers Res Ther. 2021 Oct 5;13(1):163
pubmed: 34610837
Psychosom Med. 2002 May-Jun;64(3):493-501
pubmed: 12021423
Neurology. 2022 Jun 14;98(24):e2454-e2464
pubmed: 35444054
J Alzheimers Dis. 2022;88(3):957-970
pubmed: 35723096
J Alzheimers Dis. 2022;86(3):1385-1398
pubmed: 35213368
Neuroimaging Clin N Am. 2005 Nov;15(4):853-68, xi
pubmed: 16443496
Alzheimers Dement. 2018 Feb;14(2):205-214
pubmed: 28943286
Acta Neuropathol. 2002 Jul;104(1):72-8
pubmed: 12070667
Nat Genet. 2021 Mar;53(3):392-402
pubmed: 33589840
Acta Neuropathol. 2014 Feb;127(2):151-73
pubmed: 24306942
J Alzheimers Dis. 2022;88(1):229-239
pubmed: 35570494
J Cell Physiol. 2019 Mar;234(3):2296-2305
pubmed: 30191975
IEEE J Biomed Health Inform. 2016 Mar;20(2):682-90
pubmed: 25794404
Sci Rep. 2021 Sep 23;11(1):18964
pubmed: 34556796
Curr Alzheimer Res. 2018;15(8):702-715
pubmed: 29359668
J Integr Neurosci. 2022 Mar 23;21(2):67
pubmed: 35364655
J Int Neuropsychol Soc. 2004 May;10(3):342-54
pubmed: 15147592
Cells. 2022 Apr 17;11(8):
pubmed: 35456047
J Alzheimers Dis. 2022;85(4):1441-1452
pubmed: 34958042
J Alzheimers Dis. 2022;89(2):695-708
pubmed: 35938254
J Alzheimers Dis. 2022;86(4):1875-1895
pubmed: 35253754
Eur Neurol. 1993;33(6):403-8
pubmed: 8307060
Neurobiol Aging. 2022 Oct;118:88-98
pubmed: 35908327
Int J Mol Sci. 2021 Dec 19;22(24):
pubmed: 34948414
Int J Med Sci. 2021 Jun 11;18(13):2950-2956
pubmed: 34220322
Behav Sleep Med. 2020 Sep-Oct;18(5):577-588
pubmed: 31203649
Arq Neuropsiquiatr. 2022 Jun;80(6):570-579
pubmed: 35946705
Neuropathol Appl Neurobiol. 2022 Feb;48(1):e12753
pubmed: 34297416
Methods Mol Biol. 2022;2340:197-220
pubmed: 35167076
Semin Nucl Med. 2017 Jan;47(1):75-88
pubmed: 27987560
Comput Biol Med. 2021 Dec;139:104947
pubmed: 34678481
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021 May;28(3):418-437
pubmed: 32654600
Am J Alzheimers Dis Other Demen. 2002 Jan-Feb;17(1):11-7
pubmed: 11831415
Acta Neuropathol. 2022 Sep;144(3):489-508
pubmed: 35796870
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020 Jul;27(4):567-580
pubmed: 31382824
Life (Basel). 2021 Oct 19;11(10):
pubmed: 34685479
IEEE Pulse. 2018 Nov-Dec;9(6):8-10
pubmed: 30452340
Front Aging Neurosci. 2020 Apr 01;12:77
pubmed: 32296326
Fed Regist. 1979 Apr 18;44(76):23191-7
pubmed: 10241035
J Alzheimers Dis. 2021;82(2):647-659
pubmed: 34057090
Brain Sci. 2019 Nov 25;9(12):
pubmed: 31775369
PLoS One. 2022 Apr 4;17(4):e0265764
pubmed: 35377902
Front Neurosci. 2022 Aug 05;16:938092
pubmed: 35992906
J Investig Med. 2020 Aug;68(6):1135-1140
pubmed: 32699179
J Vis Exp. 2022 May 5;(183):
pubmed: 35604169
Int J Mol Sci. 2021 Apr 27;22(9):
pubmed: 33925434
Alzheimers Res Ther. 2022 Jun 23;14(1):86
pubmed: 35739591
Front Aging Neurosci. 2022 Jul 06;14:606424
pubmed: 35875792
Aging Clin Exp Res. 2018 Aug;30(8):993-998
pubmed: 29188578
J Alzheimers Dis. 2019;70(1):35-49
pubmed: 31177211
Cell Mol Neurobiol. 2019 Mar;39(2):181-209
pubmed: 30671696
Genes (Basel). 2022 Jul 22;13(8):
pubmed: 35893045
Int J Mol Sci. 2022 Aug 20;23(16):
pubmed: 36012665
Neurorehabil Neural Repair. 2022 Jun;36(6):346-359
pubmed: 35387509
J Alzheimers Dis. 2022;86(2):511-524
pubmed: 35124638
Nat Biomed Eng. 2021 Jan;5(1):11-25
pubmed: 33318650
Cells. 2022 Jun 09;11(12):
pubmed: 35741010
Medicina (Kaunas). 2021 Dec 30;58(1):
pubmed: 35056368
Neuropsychologia. 2019 Oct;133:107191
pubmed: 31521634
Acta Ophthalmol. 2017 Dec;95(8):768-777
pubmed: 29220126
Exp Gerontol. 2000 Sep;35(6-7):831-41
pubmed: 11053674

Auteurs

Mark Stecker (M)

Fresno Institute of Neuroscience, Fresno, CA 93720, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH