G-Quadruplex Aptamer-Ligand Characterization.
G-quadruplex aptamer
aptamer–ligand interactions
biophysical techniques
ligands
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Oct 2022
11 Oct 2022
Historique:
received:
01
09
2022
revised:
30
09
2022
accepted:
07
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
In this work we explore the structure of a G-rich DNA aptamer termed AT11-L2 (TGGTGGTGGTTGTTGTTGGTGGTGGTGGT; derivative of AT11) by evaluating the formation and stability of G-quadruplex (G4) conformation under different experimental conditions such as KCl concentration, temperature, and upon binding with a variety of G4 ligands (360A, BRACO-19, PDS, PhenDC3, TMPyP4). We also determined whether nucleolin (NCL) can be a target of AT11-L2 G4. Firstly, we assessed by circular dichroism, UV and NMR spectroscopies the formation of G4 by AT11-L2. We observed that, for KCl concentrations of 65 mM or less, AT11-L2 adopts hybrid or multiple topologies. In contrast, a parallel topology predominates for buffer containing 100 mM of KCl. The
Identifiants
pubmed: 36296374
pii: molecules27206781
doi: 10.3390/molecules27206781
pmc: PMC9609330
pii:
doi:
Substances chimiques
Ligands
0
Aptamers, Nucleotide
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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