Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats.
Aspidocarpine
Aspidosperma desmanthum
alkaloid
blood pressure
rotarod
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Oct 2022
14 Oct 2022
Historique:
received:
10
09
2022
revised:
02
10
2022
accepted:
10
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions.
Identifiants
pubmed: 36296487
pii: molecules27206895
doi: 10.3390/molecules27206895
pmc: PMC9609921
pii:
doi:
Substances chimiques
Antihypertensive Agents
0
Indole Alkaloids
0
Alkaloids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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