Bioanalytical Method Development, Validation and Stability Assessment of Xanthohumol in Rat Plasma.

Rats Animals Chromatography, High Pressure Liquid / methods Chalcones Curcumin Methanol Reproducibility of Results
RP-HPLC bioanalytical method rat-plasma stability xanthohumol

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
21 Oct 2022
Historique:
received: 06 09 2022
revised: 07 10 2022
accepted: 12 10 2022
entrez: 27 10 2022
pubmed: 28 10 2022
medline: 29 10 2022
Statut: epublish

Résumé

Xanthohumol (XH) a prenylated chalcone has diverse therapeutic effects against various diseases. In the present study, a bioanalytical method was developed for XH in rat plasma using reverse phase high performance liquid chromatography. The validation of the method was performed as per ICH M10 guidelines using curcumin as an internal standard. The Isocratic elution method was used with a run time of 10 min, wherein the mobile phase ratio 0.1%

Identifiants

DOI: 10.3390/molecules27207117 PMID: 36296708 PMC: PMC9608944
pubmed: 36296708
pii: molecules27207117
doi: 10.3390/molecules27207117
pmc: PMC9608944
pii:
doi:

Substances chimiques

Chalcones 0
Curcumin IT942ZTH98
Methanol Y4S76JWI15

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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pubmed: 31095671

Auteurs

Vancha Harish (V)

School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara 144411, Punjab, India.
ORCID: 0000-0003-3651-0662

Waleed Hassan Almalki (WH)

Department of Pharmacology, Umm Al-Qura College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.

Ahmed Alshehri (A)

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.

Abdulaziz Alzahrani (A)

Pharmaceuticals Chemistry Department, Faculty of Clinical Pharmacy, Al Baha University, Al Baha 65779, Saudi Arabia.

Sami I Alzarea (SI)

Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.

Imran Kazmi (I)

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
ORCID: 0000-0003-1881-5219

Monica Gulati (M)

School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara 144411, Punjab, India.
Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.

Devesh Tewari (D)

Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, Delhi, India.
ORCID: 0000-0002-5125-3791

Dinesh Kumar Chellappan (DK)

School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
ORCID: 0000-0001-5567-6663

Gaurav Gupta (G)

School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur 302017, Rajasthan, India.
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, Tamil Nadu, India.
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, Uttarakhand, India.

Kamal Dua (K)

Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia.
ORCID: 0000-0002-7507-1159

Sachin Kumar Singh (SK)

School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara 144411, Punjab, India.
Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
ORCID: 0000-0003-3823-6572

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Bioanalytical Method Development, Validation...
questionsmedicales.fr › Eucaryotes › Animaux › Bioanalytical Method Development, Validation...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Bioanalytical Method Development, Validation...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Chalcones › Bioanalytical Method Development, Validation...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Bioanalytical Method Development, Validation...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Méthanol › Bioanalytical Method Development, Validation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Bioanalytical Method Development, Validation...