Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells.

Humans Tocotrienols / pharmacology Transcriptome Cell Line, Tumor Vitamin E / pharmacology Apoptosis Cell Proliferation Chondrosarcoma / drug therapy
anti-proliferation apoptosis cell cycle arrest endoplasmic reticulum paraptosis vitamin E

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
13 Oct 2022
Historique:
received: 10 09 2022
revised: 06 10 2022
accepted: 11 10 2022
entrez: 27 10 2022
pubmed: 28 10 2022
medline: 29 10 2022
Statut: epublish

Résumé

Previous studies have demonstrated the anticancer activities of tocotrienol on several types of cancer, but its effects on chondrosarcoma have never been investigated. Therefore, this study aims to determine the anticancer properties of annatto tocotrienol (AnTT), γ-tocotrienol (γ-T3) and δ-tocotrienol (δ-T3) on human chondrosarcoma SW1353 cells. Firstly, the MTT assay was performed to determine the half-maximal inhibitory concentration (IC

Identifiants

DOI: 10.3390/nu14204277 PMID: 36296960 PMC: PMC9611384
pubmed: 36296960
pii: nu14204277
doi: 10.3390/nu14204277
pmc: PMC9611384
pii:
doi:

Substances chimiques

plastochromanol 8 4382-43-8
tocotrienol, delta 1SRB74OWSI
annatto 6PQP1V1B6O
Tocotrienols 0
Vitamin E 1406-18-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ministry of Education, Malaysia
ID : FRGS/1/2018/SKK10/UKM/03/1

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Auteurs

Kok-Lun Pang (KL)

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia.
ORCID: 0000-0003-2219-6297

Lian-Chee Foong (LC)

State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Norzana Abd Ghafar (N)

Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia.

Ima Nirwana Soelaiman (IN)

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia.
ORCID: 0000-0001-9655-438X

Jia Xian Law (JX)

Centre for Tissue Engineering and Regenerative Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia.
ORCID: 0000-0001-9045-5145

Lek Mun Leong (LM)

Prima Nexus Sdn. Bhd., Suite 8-1 & 8-2, Level 8, Menara CIMB, Jalan Stesen Sentral 2, Kuala Lumpur 50470, Malaysia.
Department of Biomedical Science, Faculty of Science, Lincoln University College, Wisma Lincoln, No. 12-18, Jalan SS 6/12, Petaling Jaya 47301, Malaysia.

Kok-Yong Chin (KY)

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia.
ORCID: 0000-0001-6628-1552

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transcriptomic Analysis of the Anticancer...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Tocotriénols › Transcriptomic Analysis of the Anticancer...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Transcriptomic Analysis of the Anticancer...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Transcriptomic Analysis of the Anticancer...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Transcriptomic Analysis of the Anticancer...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Transcriptomic Analysis of the Anticancer...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Transcriptomic Analysis of the Anticancer...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Chondrosarcome › Transcriptomic Analysis of the Anticancer...