An Algae-Made RBD from SARS-CoV-2 Is Immunogenic in Mice.
Chlamydomonas reinhardtii
mucosal vaccine
oral vaccine boosting
sterilizing immunity
variant of concern
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
21 Oct 2022
21 Oct 2022
Historique:
received:
24
08
2022
revised:
10
10
2022
accepted:
14
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Despite the current advances in global vaccination against SARS-CoV-2, boosting is still required to sustain immunity in the population, and the induction of sterilizing immunity remains as a pending goal. Low-cost oral immunogens could be used as the basis for the design of affordable and easy-to-administer booster vaccines. Algae stand as promising platforms to produce immunogens at low cost, and it is possible to use them as oral delivery carriers since they are edible (not requiring complex purification and formulation processes). Herein, a
Identifiants
pubmed: 36297410
pii: ph15101298
doi: 10.3390/ph15101298
pmc: PMC9607479
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : 848290
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