Nanoparticles and Radioisotopes: A Long Story in a Nutshell.
drug delivery
nanoparticles
radiopharmaceuticals
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
23 Sep 2022
23 Sep 2022
Historique:
received:
18
08
2022
revised:
09
09
2022
accepted:
19
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
The purpose of this narrative review was to assess the use of nanoparticles (NPs) to deliver radionuclides to targets, focusing on systems that have been tested in pre-clinical and, when available, clinical settings. A literature search was conducted in PubMed and Web of Science databases using the following terms: "radionuclides" AND "liposomes" or "PLGA nanoparticles" or "gold nanoparticles" or "iron oxide nanoparticles" or "silica nanoparticles" or "micelles" or "dendrimers". No filters were applied, apart from a minimum limit of 10 patients enrolled for clinical studies. Data from some significant studies from pre-clinical and clinical settings were retrieved, and we briefly describe the information available. All the selected seven classes of nanoparticles were highly tested in clinical trials, but they all present many drawbacks. Liposomes are the only ones that have been tested for clinical applications, though they have never been commercialized. In conclusion, the application of NPs for imaging has been the object of much interest over the years, albeit mainly in pre-clinical settings. Thus, we think that, based on the current state, radiolabeled NPs must be investigated longer before finding their place in nuclear medicine.
Identifiants
pubmed: 36297457
pii: pharmaceutics14102024
doi: 10.3390/pharmaceutics14102024
pmc: PMC9612364
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Med Chem. 2007 Dec 27;50(26):6454-7
pubmed: 18052025
Nucl Med Biol. 2013 Nov;40(8):1018-24
pubmed: 24035550
Contrast Media Mol Imaging. 2017 May 31;2017:4693417
pubmed: 29097923
Clin Cancer Res. 2020 Jan 1;26(1):147-158
pubmed: 31515460
Nanoscale. 2018 Mar 29;10(13):6113-6124
pubmed: 29547220
J Liposome Res. 2007;17(3-4):121-37
pubmed: 18027233
Nanomedicine. 2012 Jan;8(1):112-8
pubmed: 21645641
Clin Cancer Res. 2001 Feb;7(2):243-54
pubmed: 11234875
J Liposome Res. 2010 Sep;20(3):219-27
pubmed: 19863193
Adv Drug Deliv Rev. 2020;154-155:2-12
pubmed: 32707149
J Nucl Med. 1981 Sep;22(9):810-4
pubmed: 7277025
Bioconjug Chem. 2008 Dec;19(12):2577-84
pubmed: 18991368
J Nucl Med. 2014 Oct;55(10):1706-11
pubmed: 25060196
Nanoscale. 2019 Mar 28;11(13):5909-5913
pubmed: 30888363
ACS Nano. 2016 Nov 22;10(11):9887-9898
pubmed: 27754658
Biomed Pharmacother. 2021 Feb;134:111076
pubmed: 33341054
Int J Pharm. 2016 Dec 30;515(1-2):692-701
pubmed: 27825862
ACS Nano. 2021 Nov 8;:
pubmed: 34748314
Adv Cancer Res. 2018;137:115-170
pubmed: 29405974
Cancer Lett. 2016 Jun 1;375(2):256-262
pubmed: 26987625
ACS Nano. 2016 Nov 22;10(11):10294-10307
pubmed: 27781436
Biochem Soc Trans. 1977;5(1):290-1
pubmed: 892186
J Nucl Med. 1982 Sep;23(9):810-5
pubmed: 7108630
Appl Radiat Isot. 2013 Oct;80:88-94
pubmed: 23850887
J Drug Target. 2008 May;16(4):311-20
pubmed: 18446610
Biomaterials. 2011 Mar;32(9):2334-41
pubmed: 21216003
Materials (Basel). 2020 Dec 22;14(1):
pubmed: 33375074
ACS Appl Mater Interfaces. 2020 Mar 18;12(11):12395-12406
pubmed: 32077680
Molecules. 2017 Aug 25;22(9):
pubmed: 28841180
ACS Appl Mater Interfaces. 2015 Oct 21;7(41):22796-806
pubmed: 26426093
J Control Release. 2012 Jul 20;161(2):175-87
pubmed: 21945285
Int J Mol Sci. 2019 Jan 08;20(1):
pubmed: 30626016
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1214-1221
pubmed: 32940067
Int J Mol Sci. 2018 Jul 06;19(7):
pubmed: 29986450
Br J Cancer. 1979 Jul;40(1):35-43
pubmed: 475960
Radiology. 1988 Mar;166(3):761-5
pubmed: 3340774
Biochim Biophys Acta. 1988 Oct 20;944(3):329-36
pubmed: 3179293
Nucl Med Biol. 2007 Feb;34(2):165-71
pubmed: 17307124
Biomaterials. 2014 Aug;35(25):7050-7
pubmed: 24840614
Nucl Med Biol. 2015 Jan;42(1):65-70
pubmed: 25277378
Nanomedicine. 2015 Jan;11(1):155-65
pubmed: 25200610
J Labelled Comp Radiopharm. 2014 Apr;57(4):298-303
pubmed: 24395384
EJNMMI Res. 2016 Dec;6(1):12
pubmed: 26860294
Int J Rad Appl Instrum B. 1992 Jul;19(5):539-47
pubmed: 1399684
Cancer. 1988 Sep 1;62(5):905-11
pubmed: 3409173
J Nucl Med. 2008 Aug;49(8):1371-9
pubmed: 18632815
J Control Release. 2018 Jan 10;269:100-109
pubmed: 29122662
Drug Deliv. 2020 Dec;27(1):1544-1561
pubmed: 33118416
Biomaterials. 2020 May;241:119858
pubmed: 32120314
Nanoscale. 2014 Nov 21;6(22):13501-9
pubmed: 25266128
Oncotarget. 2016 Nov 22;7(47):76635-76646
pubmed: 27791199
Sci Transl Med. 2014 Oct 29;6(260):260ra149
pubmed: 25355699
J Pharmacol Exp Ther. 2004 Feb;308(2):419-25
pubmed: 14610219
Dalton Trans. 2018 Jul 17;47(28):9283-9293
pubmed: 29796500
Curr Pharm Des. 2017;23(14):2108-2112
pubmed: 27784242
Molecules. 2019 Oct 07;24(19):
pubmed: 31591329
Int J Nanomedicine. 2015 Dec 16;10:7443-54
pubmed: 26719687
Biomaterials. 2011 Jun;32(17):4151-60
pubmed: 21367450
Eur J Med Chem. 2020 Nov 1;205:112501
pubmed: 32758860
ACS Nano. 2021 Nov 23;15(11):17348-17360
pubmed: 34405675
Eur J Nucl Med Mol Imaging. 2003 Apr;30(4):502-9
pubmed: 12536243
Eur J Pharm Sci. 2020 Aug 1;151:105412
pubmed: 32505796
J Nanosci Nanotechnol. 2020 Apr 1;20(4):2040-2044
pubmed: 31492210
Eur J Nucl Med Mol Imaging. 2016 May;43(5):941-952
pubmed: 26646780
J Nucl Med. 2012 Mar;53(3):459-63
pubmed: 22323777
Contrast Media Mol Imaging. 2020 May 6;2020:2728134
pubmed: 32489332
Ann Nucl Med. 2016 Jun;30(5):334-45
pubmed: 26897009
Biomacromolecules. 2015 Sep 14;16(9):3033-41
pubmed: 26295201
J Nucl Med. 2003 Dec;44(12):1992-9
pubmed: 14660726
Nanomedicine (Lond). 2019 Jan;14(1):5-17
pubmed: 30451578
Nat Nanotechnol. 2015 Jul;10(7):619-23
pubmed: 26076469
J Pharm Sci. 2003 Sep;92(9):1893-904
pubmed: 12950007
Anal Biochem. 1979 Apr 15;94(2):302-7
pubmed: 380400
J Nucl Med. 1978 Oct;19(10):1162-70
pubmed: 102739
Mol Imaging Biol. 2018 Oct;20(5):683-695
pubmed: 30084044
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jul;8(4):619-30
pubmed: 26692551
Acc Chem Res. 2018 Mar 20;51(3):778-788
pubmed: 29489335
Bioconjug Chem. 2014 Dec 17;25(12):2157-65
pubmed: 25322194
Cancer Chemother Pharmacol. 2014 Jul;74(1):211-5
pubmed: 24817602
PLoS One. 2012;7(3):e34019
pubmed: 22442740
J Liposome Res. 2011 Mar;21(1):17-27
pubmed: 20334497
Adv Drug Deliv Rev. 2019 Mar 15;143:134-160
pubmed: 31170428
Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110043
pubmed: 31546458
J Nucl Med Technol. 2020 Sep;48(3):269-273
pubmed: 32518123
J Clin Oncol. 1999 Nov;17(11):3512-21
pubmed: 10550149
Clin Cancer Res. 2017 Aug 1;23(15):4190-4202
pubmed: 28298546