Platinum(IV) Complexes of the 1,3,5-Triamino Analogue of the Biomolecule Cis-Inositol Designed as Innovative Antineoplastic Drug Candidates.
Pt(IV) complexes
biological activity
cisplatin resistance
novel metal-based drugs
structure-activity studies
synthesis and characterization
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
27 Sep 2022
27 Sep 2022
Historique:
received:
15
07
2022
revised:
16
09
2022
accepted:
22
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Metal complexes occupy a special place in the field of treatment and diagnostics. Their main advantages stem from the possibility of fine-tuning their thermodynamic properties and kinetic behavior in the biological milieu by applying different approaches such as properly constructed inner coordination sphere, appropriate choice of ligands, metal oxidation state, redox potential, etc., which are specific to these compounds. Here we discuss the design and synthesis of two octahedral cationic Pt(IV) complexes of the tridentate ligand all-
Identifiants
pubmed: 36297500
pii: pharmaceutics14102057
doi: 10.3390/pharmaceutics14102057
pmc: PMC9611922
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Scientific Research Fund (Project DN09/16) of the Bulgarian Ministry of Education and Science,
ID : DN09/16
Organisme : Scientific Research Fund of Sofia University
ID : 80-10-99/2022
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