Pulsed Laser Photo-Crosslinking of Gelatin Methacryloyl Hydrogels for the Controlled Delivery of Chlorpromazine to Combat Antimicrobial Resistance.
266 nm pulsed laser exposure
GelMa
Irgacure 2959
antimicrobial effect
cytotoxicity
hydrogel
photopolymerization
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
06 Oct 2022
06 Oct 2022
Historique:
received:
25
08
2022
revised:
20
09
2022
accepted:
03
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Hydrogels are ideal candidates for the sustained local administration of antimicrobial drugs because they have customizable physicochemical properties that allow drug release kinetics to be controlled and potentially address the issue of systemic side effects. Consequently, the purpose of this study was to use 266 nm-pulsed laser beams to photo-crosslink gelatin methacryloyl hydrogels using Irgacure 2959 as a photo-initiator to reduce the curing time and to have an online method to monitor the process, such as laser-induced fluorescence. Additionally, irradiated chlorpromazine was loaded into the hydrogels to obtain a drug delivery system with antimicrobial activity. These hydrogels were investigated by UV-Vis and FTIR absorption spectroscopy, scanning electron microscopy, and laser-induced fluorescence spectroscopy and their structural and morphological characteristics, swelling behavior, and drug release profile were obtained. As a result the morphology, swelling behavior, and drug release profile were influenced by both the energy of the laser beam and the exposure time. The optimal hydrogel was obtained after 1 min of laser irradiation for Irgacure 2959 at 0.05%
Identifiants
pubmed: 36297555
pii: pharmaceutics14102121
doi: 10.3390/pharmaceutics14102121
pmc: PMC9610884
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerul Cercetării și Inovării
ID : PN-III-P1-1.1-PD-2019-1117
Organisme : by Romanian National Authority for Scientific Research and Innovation
ID : Nucleu Programme, ctr. no 16N/2019
Références
J Mater Sci Mater Med. 2017 Nov 18;28(12):195
pubmed: 29151130
AMA Arch Intern Med. 1959 Aug;104(2):208-16
pubmed: 13669774
Pharm Res. 1992 Mar;9(3):283-90
pubmed: 1614957
Polymers (Basel). 2020 May 07;12(5):
pubmed: 32392892
Science. 1995 Nov 10;270(5238):908
pubmed: 7481785
Virulence. 2018 Jan 1;9(1):522-554
pubmed: 28362216
Biomaterials. 2010 Jul;31(21):5536-44
pubmed: 20417964
Gels. 2022 Mar 10;8(3):
pubmed: 35323287
J Phys Chem A. 2014 Sep 25;118(38):8701-7
pubmed: 25134065
PLoS One. 2016 Jan 13;11(1):e0146401
pubmed: 26760034
Int J Pharm. 2020 Jun 30;584:119412
pubmed: 32418898
Polymers (Basel). 2019 Aug 13;11(8):
pubmed: 31412552
Microb Pathog. 2019 Apr;129:250-256
pubmed: 30742947
J Biomed Opt. 2015 May;20(5):051002
pubmed: 25365041
Int J Biol Macromol. 2018 Dec;120(Pt B):1561-1571
pubmed: 30261261
J Biomed Mater Res A. 2009 Oct;91(1):52-9
pubmed: 18690661
Soft Matter. 2018 Mar 14;14(11):2142-2151
pubmed: 29488996
Nat Biotechnol. 2008 Nov;26(11):1261-8
pubmed: 18997767
Acta Derm Venereol. 2020 Apr 20;100(9):adv00110
pubmed: 32207539
Dermatol Clin. 2012 Jan;30(1):141-51, ix-x
pubmed: 22117875
Chem Phys Lipids. 2021 Aug;238:105101
pubmed: 34029537
Lab Chip. 2016 Oct 18;16(21):4097-4105
pubmed: 27722710
Sci Rep. 2019 May 3;9(1):6863
pubmed: 31053756
Nat Rev Mater. 2016 Dec;1(12):
pubmed: 29657852
Drug Discov Today. 2015 Nov;20(11):1293-9
pubmed: 26116094
Int J Biol Macromol. 2011 Dec 1;49(5):948-54
pubmed: 21871915
Adv Mater. 2017 Feb;29(8):
pubmed: 27982464
Bioeng Transl Med. 2017 Jul 14;2(3):258-267
pubmed: 29313035
Molecules. 2021 Jul 20;26(14):
pubmed: 34299652
J Clin Pathol. 1975 Oct;28(10):779-83
pubmed: 1214010
Molecules. 2019 Feb 08;24(3):
pubmed: 30744011
In Vivo. 2013 Sep-Oct;27(5):605-10
pubmed: 23988894
Nat Protoc. 2016 Apr;11(4):727-46
pubmed: 26985572
Dent Mater. 2022 Sep;38(9):1507-1517
pubmed: 35882570
Drug Saf. 1994 Mar;10(3):233-66
pubmed: 8043223
Curr Opin Infect Dis. 2015 Jun;28(3):253-8
pubmed: 25887613
Biomaterials. 2005 Apr;26(11):1211-8
pubmed: 15475050
Biomaterials. 2014 Jan;35(1):49-62
pubmed: 24112804
Biology (Basel). 2013 Nov 01;2(4):1268-81
pubmed: 24833224
Drug Deliv. 2017 Nov;24(1):1317-1324
pubmed: 28906151
Polymers (Basel). 2020 Feb 24;12(2):
pubmed: 32102478
J Am Acad Dermatol. 2017 May;76(5):958-972.e2
pubmed: 28259441
J Biomed Mater Res B Appl Biomater. 2009 Aug;90(2):752-9
pubmed: 19274725
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Trends Biotechnol. 2016 May;34(5):394-407
pubmed: 26867787
Biomaterials. 2017 Sep;140:115-127
pubmed: 28646685