New Insights into SARS-CoV-2 and Cancer Cross-Talk: Does a Novel Oncogenesis Driver Emerge?
COVID-19 sequelae
SARS-CoV-2
cancer
cancer progression
long-COVID
oncogenesis
oncogenic pathways
post-acute COVID-19 sequelae
post-acute sequelae of SARS-CoV-2
tumorgenesis
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
25 Sep 2022
25 Sep 2022
Historique:
received:
31
08
2022
revised:
18
09
2022
accepted:
22
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Since the pandemic's onset, a growing population of individuals has recovered from SARS-CoV-2 infection and its long-term effects in some of the convalescents are gradually being reported. Although the precise etiopathogenesis of post-acute COVID-19 sequelae (PACS) remains elusive, the mainly accepted rationale is that SARS-CoV-2 exerts long-lasting immunomodulatory effects, promotes chronic low-grade inflammation, and causes irreversible tissue damage. So far, several viruses have been causally linked to human oncogenesis, whereas chronic inflammation and immune escape are thought to be the leading oncogenic mechanisms. Excessive cytokine release, impaired T-cell responses, aberrant activation of regulatory signaling pathways (e.g., JAK-STAT, MAPK, NF-kB), and tissue damage, hallmarks of COVID-19 disease course, are also present in the tumor microenvironment. Therefore, the intersection of COVID-19 and cancer is partially recognized and the long-term effects of the virus on oncogenesis and cancer progression have not been explored yet. Herein, we present an up-to-date review of the current literature regarding COVID-19 and cancer cross-talk, as well as the oncogenic pathways stimulated by SARS-CoV-2.
Identifiants
pubmed: 36298472
pii: vaccines10101607
doi: 10.3390/vaccines10101607
pmc: PMC9611551
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Int J Mol Sci. 2020 Aug 27;21(17):
pubmed: 32867331
Cell Host Microbe. 2012 Mar 15;11(3):240-52
pubmed: 22423964
Physiol Rep. 2021 Feb;9(3):e14726
pubmed: 33523608
Int J Mol Sci. 2021 Aug 03;22(15):
pubmed: 34361112
Cancers (Basel). 2021 Jun 30;13(13):
pubmed: 34209038
Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5192-201
pubmed: 27519799
Science. 2000 Oct 13;290(5490):354-7
pubmed: 11030657
Science. 2011 Mar 25;331(6024):1565-70
pubmed: 21436444
Am J Clin Pathol. 2020 Mar 9;153(4):420-421
pubmed: 32053148
Biomed J. 2014 Sep-Oct;37(5):246-58
pubmed: 25163502
Nat Rev Microbiol. 2017 Feb;15(2):109-128
pubmed: 28045107
Cell. 2021 Feb 18;184(4):861-880
pubmed: 33497610
Lancet Microbe. 2021 Feb;2(2):e49-e50
pubmed: 33655230
FEBS Open Bio. 2019 Jan 30;9(3):478-489
pubmed: 30868056
J Infect Dis. 2021 Dec 1;224(11):1839-1848
pubmed: 34677601
Front Immunol. 2022 Mar 25;13:848886
pubmed: 35401523
Life Sci. 2021 Nov 1;284:119201
pubmed: 33607159
Front Immunol. 2022 Jun 10;13:886431
pubmed: 35757700
Transl Oncol. 2020 Oct;13(10):100814
pubmed: 32619819
Cell Biosci. 2020 Mar 10;10:31
pubmed: 32175074
Semin Cancer Biol. 2015 Dec;35 Suppl:S185-S198
pubmed: 25818339
J Investig Med. 2022 Jan;70(1):61-67
pubmed: 34611034
Front Virol. 2021 Nov;1:
pubmed: 35141704
Lancet Microbe. 2020 May;1(1):e11
pubmed: 32835323
Int J Epidemiol. 2021 Jan 23;49(6):1940-1950
pubmed: 33150437
Springer Semin Immunopathol. 2005 Jun;27(1):19-35
pubmed: 15965711
World J Gastroenterol. 2015 Aug 7;21(29):8787-803
pubmed: 26269668
J Clin Invest. 2020 Oct 1;130(10):5235-5244
pubmed: 32634129
Nat Rev Gastroenterol Hepatol. 2018 Jul;15(7):440-452
pubmed: 29670252
Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188622
pubmed: 34478803
Gut. 2022 Jan;71(1):222-225
pubmed: 33833065
Eur Respir J. 2021 Aug 26;58(2):
pubmed: 34244323
Cancer Immunol Res. 2014 Sep;2(9):823-30
pubmed: 25187272
Lung. 2021 Apr;199(2):113-119
pubmed: 33569660
Cell. 2021 Mar 18;184(6):1517-1529
pubmed: 33740452
Signal Transduct Target Ther. 2022 Mar 24;7(1):95
pubmed: 35332121
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Front Cardiovasc Med. 2021 May 26;8:681948
pubmed: 34124207
Ann Rheum Dis. 2011 Mar;70 Suppl 1:i104-8
pubmed: 21339211
Med Hypotheses. 2020 Oct;143:109882
pubmed: 32485314
EPMA J. 2019 Nov 20;10(4):365-381
pubmed: 31832112
Nat Rev Immunol. 2005 Aug;5(8):641-54
pubmed: 16056256
Nat Med. 2021 Sep;27(9):1607-1613
pubmed: 34163090
JCI Insight. 2020 Aug 6;5(15):
pubmed: 32554923
Sci Rep. 2016 Sep 08;6:32952
pubmed: 27604143
Mol Cancer. 2021 May 17;20(1):76
pubmed: 34001144
Gut. 2022 Mar;71(3):544-552
pubmed: 35082169
Oncoimmunology. 2015 Apr 1;4(7):e1016700
pubmed: 26140242
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15354-9
pubmed: 21876161
Gastroenterology. 2020 Oct;159(4):1302-1310.e5
pubmed: 32598884
J Exp Med. 2019 Jan 7;216(1):195-214
pubmed: 30578323
Nat Rev Microbiol. 2018 Nov;16(11):684-698
pubmed: 30143749
Cancers (Basel). 2019 Dec 12;11(12):
pubmed: 31842362
Cancer Cell. 2008 Jan;13(1):23-35
pubmed: 18167337
Front Microbiol. 2021 Jun 23;12:698169
pubmed: 34248921
Gut. 2021 Jul;70(7):1253-1265
pubmed: 33789966
Med Mycol. 2011 Apr;49(3):237-47
pubmed: 20807027
Nature. 2013 Apr 11;496(7444):238-42
pubmed: 23535595
J Infect. 2021 Mar;82(3):378-383
pubmed: 33450302
J Clin Invest. 2021 Jul 15;131(14):
pubmed: 34263736
Nat Cancer. 2020 Oct;1(10):946-964
pubmed: 35121872
Immunity. 2015 Sep 15;43(3):435-49
pubmed: 26377897
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9238-43
pubmed: 21562218
J Exp Med. 2017 Aug 7;214(8):2387-2404
pubmed: 28694385
Sci Immunol. 2021 Nov 12;6(65):eabk1741
pubmed: 34591653
Cancer Discov. 2020 Jul;10(7):916-921
pubmed: 32444466
Nat Metab. 2021 Jun;3(6):774-785
pubmed: 34035524
J Biomed Sci. 2017 Feb 1;24(1):10
pubmed: 28143527
Cancers (Basel). 2019 Jan 03;11(1):
pubmed: 30609850
Am J Clin Oncol. 2020 Jun;43(6):452-455
pubmed: 32304435
Immunity. 2019 Apr 16;50(4):778-795
pubmed: 30995499
Ann Oncol. 2020 Oct;31(10):1386-1396
pubmed: 32561401
Int J Cancer. 2004 Mar 20;109(2):265-73
pubmed: 14750179
Results Probl Cell Differ. 2009;49:1-15
pubmed: 19137269
Mycopathologia. 2020 Aug;185(4):599-606
pubmed: 32737747
Infect Immun. 2021 Mar 17;89(4):
pubmed: 33526565
Immunol Cell Biol. 2013 Sep;91(8):493-502
pubmed: 23797066
Nat Rev Clin Oncol. 2019 Mar;16(3):151-167
pubmed: 30523282
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9862-7
pubmed: 23696660
Int J Mol Sci. 2021 Sep 28;22(19):
pubmed: 34638785
Lancet. 2021 Jan 16;397(10270):220-232
pubmed: 33428867
Br J Cancer. 2021 Sep;125(7):939-947
pubmed: 34400804
Eur Heart J. 2020 Sep 1;41(32):3038-3044
pubmed: 32882706
Int J Mol Sci. 2022 Aug 03;23(15):
pubmed: 35955740
Gut. 2022 Aug 8;:
pubmed: 35940857
Gut. 2020 Jun;69(6):1141-1143
pubmed: 32102928
Nature. 2021 Jun;594(7862):259-264
pubmed: 33887749
Engineering (Beijing). 2020 Oct;6(10):1178-1184
pubmed: 33520333
J Virol. 2012 Apr;86(8):4294-304
pubmed: 22301153
Nat Cancer. 2020 Aug;1(8):784-788
pubmed: 35122051
Gastroenterology. 2011 Nov;141(5):1696-708.e1-2
pubmed: 21839041
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):
pubmed: 33472859
J Immunol. 2018 Sep 15;201(6):1615-1624
pubmed: 30181300
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
J Immunol. 2000 Nov 15;165(10):5502-8
pubmed: 11067903
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13631-6
pubmed: 11095741
Sci Immunol. 2019 Jun 14;4(36):
pubmed: 31201259
Cell Rep Med. 2022 Jun 21;3(6):100663
pubmed: 35732153
Signal Transduct Target Ther. 2022 Apr 29;7(1):143
pubmed: 35487886
JCI Insight. 2021 Dec 22;6(24):
pubmed: 34784300
FEBS Open Bio. 2018 Mar 09;8(4):671-679
pubmed: 29632819
Gene Rep. 2020 Sep;20:100765
pubmed: 32835132
J Exp Med. 2004 Dec 20;200(12):1581-92
pubmed: 15596524
Med Sci Monit. 2021 Jun 07;27:e933446
pubmed: 34092779
Nat Immunol. 2021 Jan;22(1):32-40
pubmed: 33277638
Front Immunol. 2019 Dec 10;10:2876
pubmed: 31921140
Biochim Biophys Acta. 2008 Mar;1782(3):127-50
pubmed: 18201576
Crit Rev Oncol Hematol. 2008 Apr;66(1):1-9
pubmed: 17913510
Biochim Biophys Acta. 2016 Mar;1858(3):567-75
pubmed: 26299818
Nat Commun. 2018 Sep 10;9(1):3663
pubmed: 30202057
Biochem J. 2017 May 16;474(11):1823-1836
pubmed: 28512250
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
JCI Insight. 2020 Jun 18;5(12):
pubmed: 32427582
Carcinogenesis. 2009 Jul;30(7):1073-81
pubmed: 19468060
Gut. 2020 Jun;69(6):973-974
pubmed: 32273292
J Exp Clin Cancer Res. 2021 Jan 25;40(1):42
pubmed: 33494784
Gut. 2019 Jul;68(7):1169-1179
pubmed: 30842211
Infect Dis (Lond). 2021 Oct;53(10):737-754
pubmed: 34024217
Science. 2020 Oct 23;370(6515):
pubmed: 32972996
Trends Immunol. 2015 Apr;36(4):265-76
pubmed: 25797516
Gut Microbes. 2021 Jan-Dec;13(1):1-19
pubmed: 33685349
Cell Death Differ. 2008 Jan;15(1):58-69
pubmed: 17948029
Nat Commun. 2020 May 22;11(1):2577
pubmed: 32444671
Cell. 2008 Jul 25;134(2):215-30
pubmed: 18662538
Oncotarget. 2017 Jun 28;8(37):61969-61981
pubmed: 28977919
J Carcinog Mutagen. 2014;5:
pubmed: 25541596
Lab Invest. 2007 Nov;87(11):1077-91
pubmed: 17724448
Front Pharmacol. 2020 Aug 28;11:578599
pubmed: 32982760
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Science. 2017 Mar 17;355(6330):1211-1215
pubmed: 28302859
J Infect Dis. 2022 Jun 15;225(12):2155-2162
pubmed: 35079804
Nat Rev Microbiol. 2021 Jan;19(1):55-71
pubmed: 32887946
Protein Cell. 2014 Apr;5(4):265-96
pubmed: 24622842
Front Immunol. 2020 Mar 31;11:526
pubmed: 32296435
Nat Med. 2020 Oct;26(10):1623-1635
pubmed: 32807934
Lancet Infect Dis. 2020 Oct;20(10):1115-1117
pubmed: 32888409
Int Immunol. 2021 Mar 1;33(3):127-148
pubmed: 33337480
Front Mol Biosci. 2021 Apr 12;8:643004
pubmed: 33912588
Nature. 2008 Jul 24;454(7203):436-44
pubmed: 18650914
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11515-20
pubmed: 11562487
Lancet. 2001 Feb 17;357(9255):539-45
pubmed: 11229684
Nat Rev Microbiol. 2017 Aug;15(8):465-478
pubmed: 28529325
Nat Rev Cancer. 2010 Dec;10(12):878-89
pubmed: 21102637
Viruses. 2014 Oct 23;6(10):4047-79
pubmed: 25341666
Biomed Pharmacother. 2022 Jan;145:112420
pubmed: 34801852
Gut Microbes. 2021 Jan-Dec;13(1):1-21
pubmed: 33678150
Cell. 2015 Jan 29;160(3):447-60
pubmed: 25619688
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
Sci Rep. 2013;3:2191
pubmed: 23846617
Rev Iberoam Micol. 2020 Apr - Jun;37(2):41-46
pubmed: 33041191
Front Cell Infect Microbiol. 2022 Apr 05;12:861703
pubmed: 35449732
Genomics Proteomics Bioinformatics. 2021 Oct;19(5):679-688
pubmed: 34560321
J Intern Med. 2022 Jun;291(6):801-812
pubmed: 35212063
J Biol Chem. 2003 Aug 8;278(32):29752-9
pubmed: 12783879
J Immunol. 2003 Jun 1;170(11):5373-81
pubmed: 12759411
Nature. 2002 Dec 19-26;420(6917):860-7
pubmed: 12490959
CA Cancer J Clin. 2017 Jul 8;67(4):326-344
pubmed: 28481406
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Clin Infect Dis. 2021 Dec 6;73(11):e4197-e4205
pubmed: 32603425
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2313-8
pubmed: 19139406
Lancet Microbe. 2020 Nov;1(7):e290-e299
pubmed: 33015653
Sci Immunol. 2020 Jul 15;5(49):
pubmed: 32669287
Front Pharmacol. 2022 May 24;13:868695
pubmed: 35685630
Clin Lab. 2021 Sep 1;67(9):
pubmed: 34542974
Oncogene. 2022 Jun;41(23):3177-3185
pubmed: 35501462
Cell Host Microbe. 2014 Mar 12;15(3):283-94
pubmed: 24629335
Nat Rev Cancer. 2021 Aug;21(8):481-499
pubmed: 34083781
Microbiome. 2021 Apr 14;9(1):91
pubmed: 33853691
Eur Respir J. 2014 Jan;43(1):276-85
pubmed: 23520315
J Mol Cell Cardiol. 2020 Jul;144:63-65
pubmed: 32422320
Immunity. 2019 Jul 16;51(1):27-41
pubmed: 31315034
J Exp Med. 2019 Jan 7;216(1):20-40
pubmed: 30322864
Cell Metab. 2015 Oct 6;22(4):658-68
pubmed: 26321659
Cell Host Microbe. 2014 Mar 12;15(3):266-82
pubmed: 24629334
Nat Immunol. 2022 Feb;23(2):210-216
pubmed: 35027728
Cell. 2014 May 22;157(5):1013-22
pubmed: 24855941
Gastroenterology. 2020 Sep;159(3):944-955.e8
pubmed: 32442562
Blood Rev. 2021 Mar;46:100743
pubmed: 32829962
Signal Transduct Target Ther. 2021 Jul 12;6(1):263
pubmed: 34248142
Nat Rev Immunol. 2013 Nov;13(11):790-801
pubmed: 24096337
Cell Mol Immunol. 2020 Feb;17(2):113-122
pubmed: 31969685
Clin Infect Dis. 2020 Dec 17;71(10):2669-2678
pubmed: 32497191
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Nat Med. 2020 Aug;26(8):1218-1223
pubmed: 32581323
J Exp Med. 2002 Aug 19;196(4):447-57
pubmed: 12186837
Gut. 2021 Apr;70(4):698-706
pubmed: 33431578
Sci Immunol. 2020 Nov 6;5(53):
pubmed: 33158975
Lancet Gastroenterol Hepatol. 2021 May;6(5):344-346
pubmed: 33711290
Front Behav Neurosci. 2019 Jun 18;13:126
pubmed: 31275120
Tumour Biol. 2016 Sep;37(9):11553-11572
pubmed: 27260630
Annu Rev Immunol. 2004;22:329-60
pubmed: 15032581
Gut. 2021 Feb;70(2):276-284
pubmed: 32690600
Semin Immunopathol. 2017 Jul;39(5):501-503
pubmed: 28674818
JCI Insight. 2021 Aug 9;6(15):
pubmed: 34143754
Immunity. 2021 Jan 12;54(1):14-18
pubmed: 33406391
Front Cell Infect Microbiol. 2022 Jun 30;12:922422
pubmed: 35846757
Microorganisms. 2021 May 30;9(6):
pubmed: 34070716
Front Mol Biosci. 2022 Jan 28;8:813175
pubmed: 35155571
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Science. 2020 Sep 4;369(6508):1210-1220
pubmed: 32788292
Cell Rep. 2021 Aug 10;36(6):109518
pubmed: 34358460
Nat Commun. 2014 Jul 08;5:4344
pubmed: 25003530
J Immunol. 2002 Apr 1;168(7):3181-7
pubmed: 11907070
Mult Scler Relat Disord. 2021 Oct;55:103268
pubmed: 34601388
Microb Ecol Health Dis. 2015 Feb 02;26:26191
pubmed: 25651997
Cells. 2021 Jan 07;10(1):
pubmed: 33430387
Clin Cancer Res. 2015 Feb 15;21(4):687-92
pubmed: 25501578
Viral Immunol. 2017 Jan/Feb;30(1):20-27
pubmed: 27830995
Nat Rev Immunol. 2006 Oct;6(10):715-27
pubmed: 16977338
Cell Host Microbe. 2020 Jun 10;27(6):992-1000.e3
pubmed: 32320677
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Ageing Res Rev. 2021 Jan;65:101205
pubmed: 33137510
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Annu Rev Immunol. 2004;22:531-62
pubmed: 15032588
Acta Pharmacol Sin. 2020 Dec;41(12):1539-1546
pubmed: 33110240
Bioessays. 2021 Jun;43(6):e2000331
pubmed: 33914346
Sci Rep. 2021 Aug 9;11(1):16144
pubmed: 34373540
Chest. 2020 Mar;157(3):603-611
pubmed: 31689414
JAMA Netw Open. 2021 Feb 1;4(2):e210830
pubmed: 33606031
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
Front Microbiol. 2022 Feb 10;13:789882
pubmed: 35222327
PLoS Pathog. 2017 Sep 21;13(9):e1006480
pubmed: 28934351
Cell. 2014 Mar 27;157(1):142-50
pubmed: 24679532
Curr Opin Microbiol. 2011 Aug;14(4):386-91
pubmed: 21802979
Nat Med. 2020 Apr;26(4):502-505
pubmed: 32284613
Biochem J. 2022 Feb 17;479(4):537-559
pubmed: 35195253
J Immunol. 2005 Sep 1;175(5):3110-6
pubmed: 16116200
Lancet Haematol. 2020 Oct;7(10):e737-e745
pubmed: 32798473
Cancer Res. 2005 Jul 1;65(13):5945-52
pubmed: 15994973
Front Cell Dev Biol. 2019 Jan 29;7:4
pubmed: 30761299
Immunity. 2015 Feb 17;42(2):344-355
pubmed: 25680274
Nat Rev Cancer. 2009 May;9(5):361-71
pubmed: 19343034
Commun Biol. 2021 Apr 13;4(1):480
pubmed: 33850296
Nat Med. 2003 Oct;9(10):1269-74
pubmed: 14502282
Rep Pract Oncol Radiother. 2020 May-Jun;25(3):422-427
pubmed: 32372882
Bioessays. 2021 Aug;43(8):e2000289
pubmed: 34081334
Nat Rev Immunol. 2012 Mar 22;12(4):253-68
pubmed: 22437938