Bilateral asymptomatic macular hypopigmentation in a young woman: multimodal imaging and pathogenetic hypothesis.
Macular retinal hypopigmentation
Near-infrared autofluorescence
Optical coherence tomography
Retinal pigment epithelium
Short-wavelength autofluorescence
Journal
American journal of ophthalmology case reports
ISSN: 2451-9936
Titre abrégé: Am J Ophthalmol Case Rep
Pays: United States
ID NLM: 101679941
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
02
06
2022
revised:
06
10
2022
accepted:
09
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
Macular retinal pigment epithelium (RPE) hypopigmentation is a recently described very rare condition and its pathogenesis is not completely understood. We report the case of a 23-year-old female who presented with bilateral whitish, oval-shaped foveal lesions and we speculated about the possible etiopathogenetic origin. A 23-year-old female presented to our consideration for a routine ophthalmology visit. Visual acuity was 20/20 in both eyes. The fundus examination revealed a perifoveal choroidal nevus in the right eye and a bilateral yellowish, oval-shaped lesion centered on the fovea. Imaging tests (Spectral Domain-Optical Coherence Tomography, short wavelength and near-infrared autofluorescence) and functional tests (microperimetry and multifocal electroretinogram) were within normal limits, supporting the diagnosis of macular hypopigmentation without functional loss. A complex dysregulation of both choroidal and RPE with melanin loss may be responsible for this condition.
Identifiants
pubmed: 36299983
doi: 10.1016/j.ajoc.2022.101725
pii: S2451-9936(22)00471-6
pmc: PMC9589140
doi:
Types de publication
Case Reports
Langues
eng
Pagination
101725Informations de copyright
© 2022 The Authors.
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