Mobilization of CD11b
CCR2
MCP-1
MODS
acute pancreatitis
monocytes
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
07
2022
accepted:
23
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Acute pancreatitis (AP) is an inflammatory disorder, the severe form of which is burdened with multi-organ dysfunction and high mortality. The pathogenesis of life -threatening organ complications, such as respiratory and renal failure, is unknown. Organ dysfunction was investigated in a mouse model of AP. The influence of monocytes and neutrophils on multi organ dysfunction syndrome (MODS) was investigated Similar to AP in humans, severe disease in the mouse model associates with organ dysfunction mainly of lung and kidney, which is triggered by a mobilisation of Ly6g In AP, the physical properties of mobilized monocytes, especially their large size, result in an obstruction of the fine capillary systems of the lung and of the kidney glomeruli. A selective depletion of monocytes may represent a treatment strategy for pancreatitis as well as for other inflammation-related disorders.
Identifiants
pubmed: 36300116
doi: 10.3389/fimmu.2022.991295
pmc: PMC9589437
doi:
Substances chimiques
Chemokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
991295Informations de copyright
Copyright © 2022 Wilden, Glaubitz, Otto, Biedenweg, Nauck, Mack, Ribback, Bröker, Rheinbaben, Lerch, Aghdassi, Weiss and Sendler.
Déclaration de conflit d'intérêts
OO is co-founder of Zellmechanik Dresden GmbH distributing the technology of real-time deformability cytometry. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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