PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo.
B cells
age-associated B cells
gold nanoparticles
in vivo toxicity
polymer-coating
targeted delivery
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
22 11 2022
22 11 2022
Historique:
pubmed:
28
10
2022
medline:
1
12
2022
entrez:
27
10
2022
Statut:
ppublish
Résumé
Engineered gold nanoparticles (GNPs) have become a useful tool in various therapeutic and diagnostic applications. Uncertainty remains regarding the possible impact of GNPs on the immune system. In this regard, we investigated the interactions of polymer-coated GNPs with B cells and their functions in mice. Surprisingly, we observed that polymer-coated GNPs mainly interact with the recently identified subpopulation of B lymphocytes named age-associated B cells (ABCs). Importantly, we also showed that GNPs did not affect cell viability or the percentages of other B cell populations in different organs. Furthermore, GNPs did not activate B cell innate-like immune responses in any of the tested conditions, nor did they impair adaptive B cell responses in immunized mice. Together, these data provide an important contribution to the otherwise limited knowledge about GNP interference with B cell immune function, and demonstrate that GNPs represent a safe tool to target ABCs
Identifiants
pubmed: 36301574
doi: 10.1021/acsnano.2c04871
pmc: PMC9706664
doi:
Substances chimiques
Gold
7440-57-5
Polyethylene Glycols
3WJQ0SDW1A
Polymers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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