Entorhinal-Hippocampal Circuit Integrity Is Related to Mnemonic Discrimination and Amyloid-β Pathology in Older Adults.
Alzheimer's disease
aging
amyloid-β
functional connectivity
hippocampus
memory
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
16 11 2022
16 11 2022
Historique:
received:
14
06
2022
revised:
30
09
2022
accepted:
04
10
2022
pubmed:
28
10
2022
medline:
22
11
2022
entrez:
27
10
2022
Statut:
ppublish
Résumé
Mnemonic discrimination, a cognitive process that relies on hippocampal pattern separation, is one of the first memory domains to decline in aging and preclinical Alzheimer's disease. We tested whether functional connectivity (FC) within the entorhinal-hippocampal circuit, measured with high-resolution resting state fMRI, is associated with mnemonic discrimination and amyloid-β (Aβ) pathology in a sample of 64 cognitively normal human older adults (mean age, 71.3 ± 6.4 years; 67% female). FC was measured between entorhinal-hippocampal circuit nodes with known anatomical connectivity, as well as within cortical memory networks. Aβ pathology was measured with
Identifiants
pubmed: 36302636
pii: JNEUROSCI.1165-22.2022
doi: 10.1523/JNEUROSCI.1165-22.2022
pmc: PMC9671577
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
8742-8753Subventions
Organisme : NIA NIH HHS
ID : F32 AG074621
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053555
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
Références
Learn Mem. 2010 May 21;17(6):284-8
pubmed: 20495062
Alzheimers Dement (Amst). 2020 Aug 25;12(1):e12068
pubmed: 32875052
J Neurosci. 2021 Apr 28;41(17):3917-3931
pubmed: 33731446
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
Sci Rep. 2021 Apr 27;11(1):9068
pubmed: 33907199
Hippocampus. 2011 Sep;21(9):968-79
pubmed: 20865732
J Neurosci. 2022 Feb 16;42(7):1352-1361
pubmed: 34965972
Elife. 2019 Sep 02;8:
pubmed: 31475904
J Neurosci. 2019 Oct 30;39(44):8788-8797
pubmed: 31541019
Hippocampus. 2016 Apr;26(4):417-22
pubmed: 26691235
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Brain. 2020 Apr 1;143(4):1233-1248
pubmed: 32252068
Nat Neurosci. 2018 Feb;21(2):163-173
pubmed: 29371654
Cereb Cortex. 2012 Aug;22(8):1813-23
pubmed: 21945849
Cereb Cortex. 2021 Aug 26;31(10):4781-4793
pubmed: 34037210
Hippocampus. 2019 Jun;29(6):527-538
pubmed: 30318785
Acta Neuropathol. 1985;68(4):325-32
pubmed: 4090943
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Neuropsychologia. 2013 Oct;51(12):2442-9
pubmed: 23313292
Hum Brain Mapp. 2015 Jan;36(1):258-87
pubmed: 25181316
J Neurosci. 2016 Jul 20;36(29):7569-79
pubmed: 27445136
Neurobiol Learn Mem. 2016 Mar;129:107-12
pubmed: 26149893
J Neurosci. 2014 Apr 9;34(15):5200-10
pubmed: 24719099
Ann Neurol. 2012 Oct;72(4):578-86
pubmed: 23109153
J Neurosci. 2019 Jan 16;39(3):548-556
pubmed: 30482786
Magn Reson Imaging. 2007 Jul;25(6):894-901
pubmed: 17490845
Brain. 2019 Aug 1;142(8):2492-2509
pubmed: 31199481
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Science. 2008 Sep 19;321(5896):1686-9
pubmed: 18802001
Prog Brain Res. 2007;163:43-61
pubmed: 17765711
Neurobiol Dis. 2017 Dec;108:261-276
pubmed: 28860088
Neurobiol Aging. 2018 May;65:86-97
pubmed: 29454154
Hippocampus. 2013 Jan;23(1):1-6
pubmed: 22815064
Nat Rev Neurosci. 2012 Oct;13(10):713-26
pubmed: 22992647
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4264-73
pubmed: 25246569
Neuron. 2018 Mar 7;97(5):1187-1198.e4
pubmed: 29518359
J Neurosci. 2017 Mar 22;37(12):3192-3201
pubmed: 28213439
Neurobiol Aging. 2017 Sep;57:195-205
pubmed: 28578804
Nat Neurosci. 2010 Jul;13(7):812-8
pubmed: 20581818
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Learn Mem. 2019 Jun 17;26(7):219-228
pubmed: 31209116
Trends Neurosci. 2006 Dec;29(12):662-70
pubmed: 17046075
Neurobiol Aging. 1997 Jul-Aug;18(4):351-7
pubmed: 9330961
Neuroimage. 2015 Jan 15;105:536-51
pubmed: 25462692
Elife. 2015 Jun 08;4:
pubmed: 26052749
J Neurosci. 2017 Apr 19;37(16):4323-4331
pubmed: 28314821
Hippocampus. 2019 Nov;29(11):1049-1062
pubmed: 31058404
Front Syst Neurosci. 2018 Dec 11;12:61
pubmed: 30618655
Sci Transl Med. 2021 Jan 20;13(577):
pubmed: 33472953
Neurobiol Aging. 2022 Apr;112:151-160
pubmed: 35182842
Neuroimage. 2010 Jul 1;51(3):1242-52
pubmed: 20338246
Cortex. 2021 Apr;137:138-148
pubmed: 33611227
Trends Neurosci. 2011 Oct;34(10):515-25
pubmed: 21788086
Acta Neuropathol. 2014 Dec;128(6):755-66
pubmed: 25348064
AJNR Am J Neuroradiol. 1998 Apr;19(4):659-71
pubmed: 9576651
Neuron. 2012 May 10;74(3):467-74
pubmed: 22578498
J Alzheimers Dis. 2013;37(1):41-50
pubmed: 23780659
Elife. 2015 Jun 08;4:
pubmed: 26052748
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20130369
pubmed: 24366146
Exp Gerontol. 2003 Jan-Feb;38(1-2):71-7
pubmed: 12543263
Age (Dordr). 2006 Sep;28(3):221-33
pubmed: 22253491
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8873-8
pubmed: 21555581
Hippocampus. 2017 Jan;27(1):3-11
pubmed: 27862600
J Neurosci. 2005 Jul 20;25(29):6877-86
pubmed: 16033897
Brain. 2015 Apr;138(Pt 4):1023-35
pubmed: 25678559
Ann Neurol. 2021 Sep;90(3):391-406
pubmed: 34279043
Hippocampus. 2014 Mar;24(3):303-14
pubmed: 24167060
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573